2w8s: Difference between revisions

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<StructureSection load='2w8s' size='340' side='right'caption='[[2w8s]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2w8s' size='340' side='right'caption='[[2w8s]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2w8s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"phytomonas_caryophylli"_burkholder_1942 "phytomonas caryophylli" burkholder 1942]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W8S FirstGlance]. <br>
<table><tr><td colspan='2'>[[2w8s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trinickia_caryophylli Trinickia caryophylli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W8S FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FGL:2-AMINOPROPANEDIOIC+ACID'>FGL</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FGL:2-AMINOPROPANEDIOIC+ACID'>FGL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w8s OCA], [https://pdbe.org/2w8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w8s RCSB], [https://www.ebi.ac.uk/pdbsum/2w8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w8s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w8s OCA], [https://pdbe.org/2w8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w8s RCSB], [https://www.ebi.ac.uk/pdbsum/2w8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w8s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BCPMH_TRICW BCPMH_TRICW] Hydrolytic enzyme with a broad substrate specificity acting on phosphate diesters and phosphonate monoesters (PubMed:8824203, PubMed:20133613). Hydrolyzes phosphate mono- and triesters, sulfate monoesters and sulfonate monoesters (PubMed:20133613). Hydrolyzes glyphosate monoesters. Does not hydrolyze DNA or cGMP (PubMed:8824203). Hydrolyzes glyceryl glyphosate, but this substrate has a much lower affinity than the glyphosate monoesters (PubMed:8824203, PubMed:8771792).<ref>PMID:20133613</ref> <ref>PMID:8771792</ref> <ref>PMID:8824203</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Phytomonas caryophylli burkholder 1942]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hollfelder, F]]
[[Category: Trinickia caryophylli]]
[[Category: Hyvonen, M]]
[[Category: Hollfelder F]]
[[Category: Jonas, S]]
[[Category: Hyvonen M]]
[[Category: Loo, B van]]
[[Category: Jonas S]]
[[Category: Alkaline phosphatase superfamily]]
[[Category: Van Loo B]]
[[Category: Catalytic promiscuity]]
[[Category: Formylglycine]]
[[Category: Hydrolase]]
[[Category: Phosphodiesterase]]
[[Category: Phosphonate monoester hydrolase]]

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