2w3q: Difference between revisions

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-==STRUCTURE AND INHIBITION OF THE CO2-SENSING CARBONIC ANHYDRASE CAN2 FROM THE PATHOGENIC FUNGUS CRYPTOCOCCUS NEOFORMANS==
-<StructureSection load='2w3q' size='340' side='right' caption='[[2w3q]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
+==Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans==
+<StructureSection load='2w3q' size='340' side='right'caption='[[2w3q]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2w3q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryptococcus_neoformans Cryptococcus neoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3Q FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2w3q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptococcus_neoformans Cryptococcus neoformans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3Q FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2w3n|2w3n]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3q OCA], [https://pdbe.org/2w3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3q RCSB], [https://www.ebi.ac.uk/pdbsum/2w3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3q ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w3q RCSB], [http://www.ebi.ac.uk/pdbsum/2w3q PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q3I4V7_CRYNV Q3I4V7_CRYNV]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3q_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3q_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w3q ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 26: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2w3q" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Carbonic anhydrase|Carbonic anhydrase]]
+*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Carbonate dehydratase]]
 [[Category: Cryptococcus neoformans]]
-[[Category: Gertz, M]]
+[[Category: Large Structures]]
-[[Category: Hall, R A]]
+[[Category: Gertz M]]
-[[Category: Middelhaufe, S]]
+[[Category: Hall RA]]
-[[Category: Muehlschlegel, F A]]
+[[Category: Middelhaufe S]]
-[[Category: Schlicker, C]]
+[[Category: Muehlschlegel FA]]
-[[Category: Steegborn, C]]
+[[Category: Schlicker C]]
-[[Category: Supuran, C T]]
+[[Category: Steegborn C]]
-[[Category: Vullo, D]]
+[[Category: Supuran CT]]
-[[Category: Beta-class carbonic anhydrase]]
+[[Category: Vullo D]]
-[[Category: Cryptococcus neoforman]]
-[[Category: Inhibition]]
-[[Category: Lyase]]
-[[Category: Sulfonamide]]