2w22: Difference between revisions

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-==ACTIVATION MECHANISM OF BACTERIAL THERMOALKALOPHILIC LIPASES==
-<StructureSection load='2w22' size='340' side='right' caption='[[2w22]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+==Activation Mechanism of Bacterial Thermoalkalophilic Lipases==
+<StructureSection load='2w22' size='340' side='right'caption='[[2w22]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2w22]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermocatenulatus Geobacillus thermocatenulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W22 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W22 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2w22]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_thermocatenulatus Geobacillus thermocatenulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W22 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EGC:2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>EGC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EGC:2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>EGC</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w22 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w22 RCSB], [http://www.ebi.ac.uk/pdbsum/2w22 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w22 OCA], [https://pdbe.org/2w22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w22 RCSB], [https://www.ebi.ac.uk/pdbsum/2w22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w22 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q59260_9BACI Q59260_9BACI]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w22_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w2/2w22_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w22 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 25: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2w22" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Lipase|Lipase]]
+*[[Lipase 3D Structures|Lipase 3D Structures]]
 == References ==
 <references/>
@@ Line 33: / Line 37: @@
 </StructureSection>
 [[Category: Geobacillus thermocatenulatus]]
-[[Category: Triacylglycerol lipase]]
+[[Category: Large Structures]]
-[[Category: Carrasco-Lopez, C]]
+[[Category: Carrasco-Lopez C]]
-[[Category: Fernandez-Lafuente, R]]
+[[Category: De Las Rivas B]]
-[[Category: Fernandez-Lorente, G]]
+[[Category: Fernandez-Lafuente R]]
-[[Category: Godoy, C]]
+[[Category: Fernandez-Lorente G]]
-[[Category: Guisan, J M]]
+[[Category: Godoy C]]
-[[Category: Hermoso, J A]]
+[[Category: Guisan JM]]
-[[Category: Palomo, J M]]
+[[Category: Hermoso JA]]
-[[Category: Rivas, B De Las]]
+[[Category: Palomo JM]]
-[[Category: Activation mechanism]]
-[[Category: Hydrolase]]
-[[Category: Open conformation]]
-[[Category: Thermoalkalophilic lipase]]