2vux: Difference between revisions

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-{{Seed}}
-[[Image:2vux.jpg|left|200px]]
-<!--
+==Human ribonucleotide reductase, subunit M2 B==
-The line below this paragraph, containing "STRUCTURE_2vux", creates the "Structure Box" on the page.
+<StructureSection load='2vux' size='340' side='right'caption='[[2vux]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2vux]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VUX FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
-{{STRUCTURE_2vux|  PDB=2vux  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vux OCA], [https://pdbe.org/2vux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vux RCSB], [https://www.ebi.ac.uk/pdbsum/2vux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vux ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/RIR2B_HUMAN RIR2B_HUMAN] Defects in RRM2B are the cause of mitochondrial DNA depletion syndrome type 8A (MTDPS8A) [MIM:[https://omim.org/entry/612075 612075]. A disorder due to mitochondrial dysfunction characterized by various combinations of neonatal hypotonia, neurological deterioration, respiratory distress, lactic acidosis, and renal tubulopathy.<ref>PMID:17486094</ref> <ref>PMID:18504129</ref>   Defects in RRM2B are the cause of mitochondrial DNA depletion syndrome type 8B (MTDPS8B) [MIM:[https://omim.org/entry/612075 612075]. A disease due to mitochondrial dysfunction and characterized by ophthalmoplegia, ptosis, gastrointestinal dysmotility, cachexia, peripheral neuropathy.  Defects in RRM2B are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 5 (PEOA5) [MIM:[https://omim.org/entry/613077 613077]. A disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.<ref>PMID:19664747</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/RIR2B_HUMAN RIR2B_HUMAN] Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.<ref>PMID:10716435</ref> <ref>PMID:11517226</ref> <ref>PMID:11719458</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vu/2vux_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vux ConSurf].
+<div style="clear:both"></div>
-===HUMAN RIBONUCLEOTIDE REDUCTASE, SUBUNIT M2 B===
+==See Also==
+*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-VUX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUX OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Ribonucleoside-diphosphate reductase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Andersson J]]
-[[Category: Andersson, J.]]
+[[Category: Arrowsmith CH]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Berglund H]]
-[[Category: Berg, S Van Den.]]
+[[Category: Busam RD]]
-[[Category: Berglund, H.]]
+[[Category: Collins R]]
-[[Category: Busam, R D.]]
+[[Category: Dahlgren LG]]
-[[Category: Collins, R.]]
+[[Category: Edwards AM]]
-[[Category: Dahlgren, L G.]]
+[[Category: Flodin S]]
-[[Category: Edwards, A M.]]
+[[Category: Flores A]]
-[[Category: Flodin, S.]]
+[[Category: Graslund S]]
-[[Category: Flores, A.]]
+[[Category: Hammarstrom M]]
-[[Category: Graslund, S.]]
+[[Category: Herman MD]]
-[[Category: Hammarstrom, M.]]
+[[Category: Johansson A]]
-[[Category: Herman, M D.]]
+[[Category: Johansson I]]
-[[Category: Johansson, A.]]
+[[Category: Kallas A]]
-[[Category: Johansson, I.]]
+[[Category: Karlberg T]]
-[[Category: Kallas, A.]]
+[[Category: Kotenyova T]]
-[[Category: Karlberg, T.]]
+[[Category: Lehtio L]]
-[[Category: Kotenyova, T.]]
+[[Category: Moche M]]
-[[Category: Lehtio, L.]]
+[[Category: Nilsson ME]]
-[[Category: Moche, M.]]
+[[Category: Nordlund P]]
-[[Category: Nilsson, M E.]]
+[[Category: Nyman T]]
-[[Category: Nordlund, P.]]
+[[Category: Persson C]]
-[[Category: Nyman, T.]]
+[[Category: Sagemark J]]
-[[Category: Persson, C.]]
+[[Category: Schueler H]]
-[[Category: Sagemark, J.]]
+[[Category: Svensson L]]
-[[Category: Schueler, H.]]
+[[Category: Thorsell AG]]
-[[Category: Sgc, Structural Genomics Consortium.]]
+[[Category: Tresaugues L]]
-[[Category: Svensson, L.]]
+[[Category: Weigelt J]]
-[[Category: Thorsell, A G.]]
+[[Category: Welin M]]
-[[Category: Tresaugues, L.]]
+[[Category: Wikstrom M]]
-[[Category: Weigelt, J.]]
+[[Category: Van Den Berg S]]
-[[Category: Welin, M.]]
-[[Category: Wikstrom, M.]]
-[[Category: Alternative splicing]]
-[[Category: Casp8]]
-[[Category: Cytoplasm]]
-[[Category: De novo pathway]]
-[[Category: Dna damage]]
-[[Category: Dna repair]]
-[[Category: Dna replication]]
-[[Category: Iron]]
-[[Category: Iron binding]]
-[[Category: Metal-binding]]
-[[Category: Nucleotide metabolism]]
-[[Category: Nucleus]]
-[[Category: Oxidoreductase]]
-[[Category: P53r2]]
-[[Category: Polymorphism]]
-[[Category: Ribonucleotide reductase]]
-[[Category: Rnr]]
-[[Category: Subunit m2 b]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 16 10:44:42 2008''