2vsv: Difference between revisions

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[[Image:2vsv.png|left|200px]]


<!--
==Crystal structure of the PDZ domain of human rhophilin-2==
The line below this paragraph, containing "STRUCTURE_2vsv", creates the "Structure Box" on the page.
<StructureSection load='2vsv' size='340' side='right'caption='[[2vsv]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2vsv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VSV FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsv OCA], [https://pdbe.org/2vsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vsv RCSB], [https://www.ebi.ac.uk/pdbsum/2vsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsv ProSAT]</span></td></tr>
{{STRUCTURE_2vsv|  PDB=2vsv  |  SCENE= }}
</table>
 
== Function ==
===CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOPHILIN-2===
[https://www.uniprot.org/uniprot/RHPN2_HUMAN RHPN2_HUMAN] Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.<ref>PMID:12221077</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2VSV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSV OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vsv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vsv ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Burgess-Brown, N.]]
[[Category: Bountra C]]
[[Category: Delft, F Von.]]
[[Category: Burgess-Brown N]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Elkins, J.]]
[[Category: Elkins J]]
[[Category: Kochan, G.]]
[[Category: Kochan G]]
[[Category: Murray, J W.]]
[[Category: Murray JW]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: Pike, A C.W.]]
[[Category: Pike ACW]]
[[Category: Pilka, E S.]]
[[Category: Pilka ES]]
[[Category: Roos, A.]]
[[Category: Roos A]]
[[Category: Shafqat, N.]]
[[Category: Shafqat N]]
[[Category: Sun, Z.]]
[[Category: Sun Z]]
[[Category: Wikstrom, M.]]
[[Category: Wikstrom M]]
[[Category: Casp8]]
[[Category: Von Delft F]]
[[Category: Cytoplasm]]
[[Category: Nitration]]
[[Category: Pdz domain]]
[[Category: Protein-binding]]
[[Category: Rho gtpase binding]]
[[Category: Rhob]]
[[Category: Scaffold protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:10:06 2009''

Latest revision as of 18:31, 13 December 2023

Crystal structure of the PDZ domain of human rhophilin-2Crystal structure of the PDZ domain of human rhophilin-2

Structural highlights

2vsv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.82Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RHPN2_HUMAN Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. J Biol Chem. 2002 Nov 15;277(46):43924-32. PMID:12221077 doi:10.1074/jbc.M203569200

2vsv, resolution 1.82Å

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