2vsv: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(One intermediate revision by the same user not shown)
Line 3: Line 3:
<StructureSection load='2vsv' size='340' side='right'caption='[[2vsv]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='2vsv' size='340' side='right'caption='[[2vsv]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vsv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VSV FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vsv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VSV FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsv OCA], [http://pdbe.org/2vsv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vsv RCSB], [http://www.ebi.ac.uk/pdbsum/2vsv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsv ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsv OCA], [https://pdbe.org/2vsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vsv RCSB], [https://www.ebi.ac.uk/pdbsum/2vsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHPN2_HUMAN RHPN2_HUMAN] Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.<ref>PMID:12221077</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 16: Line 19:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vsv ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vsv ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown N]]
[[Category: Delft, F von]]
[[Category: Edwards A]]
[[Category: Edwards, A]]
[[Category: Elkins J]]
[[Category: Elkins, J]]
[[Category: Kochan G]]
[[Category: Kochan, G]]
[[Category: Murray JW]]
[[Category: Murray, J W]]
[[Category: Oppermann U]]
[[Category: Oppermann, U]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W]]
[[Category: Pilka ES]]
[[Category: Pilka, E S]]
[[Category: Roos A]]
[[Category: Roos, A]]
[[Category: Shafqat N]]
[[Category: Shafqat, N]]
[[Category: Sun Z]]
[[Category: Sun, Z]]
[[Category: Wikstrom M]]
[[Category: Wikstrom, M]]
[[Category: Von Delft F]]
[[Category: Casp8]]
[[Category: Cytoplasm]]
[[Category: Nitration]]
[[Category: Pdz domain]]
[[Category: Protein binding]]
[[Category: Protein-binding]]
[[Category: Rho gtpase binding]]
[[Category: Rhob]]
[[Category: Scaffold protein]]

Latest revision as of 18:31, 13 December 2023

Crystal structure of the PDZ domain of human rhophilin-2Crystal structure of the PDZ domain of human rhophilin-2

Structural highlights

2vsv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.82Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RHPN2_HUMAN Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. J Biol Chem. 2002 Nov 15;277(46):43924-32. PMID:12221077 doi:10.1074/jbc.M203569200

2vsv, resolution 1.82Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2vsv&oldid=3988268"