2vpd: Difference between revisions

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-[[Image:2vpd.png|left|200px]]
-{{STRUCTURE_2vpd|  PDB=2vpd  |  SCENE=  }}
+==Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex==
+<StructureSection load='2vpd' size='340' side='right'caption='[[2vpd]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2vpd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VPD FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpd OCA], [https://pdbe.org/2vpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vpd RCSB], [https://www.ebi.ac.uk/pdbsum/2vpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vpd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PYGO1_HUMAN PYGO1_HUMAN] Involved in signal transduction through the Wnt pathway.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vpd_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vpd ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Pygo and BCL9/Legless transduce the Wnt signal by promoting the transcriptional activity of beta-catenin/Armadillo in normal and malignant cells. We show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me). The crystal structures of ternary complexes between PHD, HD1, and two different H3K4me peptides reveal a unique mode of histone tail recognition: efficient histone binding requires HD1 association, and the PHD-HD1 complex binds preferentially to H3K4me2 while displaying insensitivity to methylation of H3R2. Therefore, this is a prime example of histone tail binding by a PHD finger (of Pygo) being modulated by a cofactor (BCL9/Legless). Rescue experiments in Drosophila indicate that Wnt signaling outputs depend on histone decoding. The specificity of this process provided by the Pygo-BCL9/Legless complex suggests that this complex facilitates an early step in the transition from gene silence to Wnt-induced transcription.
-===DECODING OF METHYLATED HISTONE H3 TAIL BY THE PYGO-BCL9 WNT SIGNALING COMPLEX===
+Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex.,Fiedler M, Sanchez-Barrena MJ, Nekrasov M, Mieszczanek J, Rybin V, Muller J, Evans P, Bienz M Mol Cell. 2008 May 23;30(4):507-18. PMID:18498752<ref>PMID:18498752</ref>
-{{ABSTRACT_PUBMED_18498752}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 2vpd" style="background-color:#fffaf0;"></div>
-[[2vpd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPD OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:018498752</ref><references group="xtra"/>
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Bienz, M.]]
+[[Category: Large Structures]]
-[[Category: Evans, P.]]
+[[Category: Bienz M]]
-[[Category: Fiedler, M.]]
+[[Category: Evans P]]
-[[Category: Mieszczanek, J.]]
+[[Category: Fiedler M]]
-[[Category: Muller, J.]]
+[[Category: Mieszczanek J]]
-[[Category: Nekrasov, M.]]
+[[Category: Muller J]]
-[[Category: Rybin, V.]]
+[[Category: Nekrasov M]]
-[[Category: Sanchez-Barrena, M J.]]
+[[Category: Rybin V]]
-[[Category: Bcl9 hd1 domain]]
+[[Category: Sanchez-Barrena MJ]]
-[[Category: Gene regulation]]
-[[Category: Histone h3k4me2]]
-[[Category: Hpygo1 phd domain]]
-[[Category: Metal-binding]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Proto-oncogene]]
-[[Category: Signaling protein]]
-[[Category: Wnt signaling complex]]
-[[Category: Wnt signaling pathway]]
-[[Category: Zinc-finger]]