2vi9: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2vi9.png|left|200px]]
-{{STRUCTURE_2vi9|  PDB=2vi9  |  SCENE=  }}
+==Crystal structure of S172AbsSHMT Glycine external aldimine==
+<StructureSection load='2vi9' size='340' side='right'caption='[[2vi9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2vi9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VI9 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vi9 OCA], [https://pdbe.org/2vi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vi9 RCSB], [https://www.ebi.ac.uk/pdbsum/2vi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vi9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q7SIB6_GEOSE Q7SIB6_GEOSE] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vi/2vi9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vi9 ConSurf].
+<div style="clear:both"></div>
-===CRYSTAL STRUCTURE OF S172ABSSHMT GLYCINE EXTERNAL ALDIMINE===
+==See Also==
+*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[2vi9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VI9 OCA].
 [[Category: Geobacillus stearothermophilus]]
-[[Category: Glycine hydroxymethyltransferase]]
+[[Category: Large Structures]]
-[[Category: Bhavani, B S.]]
+[[Category: Appaji Rao N]]
-[[Category: Murthy, M R.N.]]
+[[Category: Bhavani BS]]
-[[Category: Prakash, V.]]
+[[Category: Murthy MRN]]
-[[Category: Rajaram, V.]]
+[[Category: Prakash V]]
-[[Category: Rao, N Appaji.]]
+[[Category: Rajaram V]]
-[[Category: Savithri, H S.]]
+[[Category: Savithri HS]]
-[[Category: E53q]]
-[[Category: Enzyme memory]]
-[[Category: Fthf]]
-[[Category: One-carbon metabolism]]
-[[Category: Plp-dependent enzyme]]
-[[Category: Pyridoxal phosphate]]
-[[Category: Shmt]]
-[[Category: Transferase]]