2vf2: Difference between revisions

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 <StructureSection load='2vf2' size='340' side='right'caption='[[2vf2]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2vf2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VF2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2vf2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VF2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2,6-dioxo-6-phenylhexa-3-enoate_hydrolase 2,6-dioxo-6-phenylhexa-3-enoate hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.7.1.8 3.7.1.8] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf2 OCA], [http://pdbe.org/2vf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vf2 RCSB], [http://www.ebi.ac.uk/pdbsum/2vf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vf2 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vf2 OCA], [https://pdbe.org/2vf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vf2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vf2 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/HSAD_MYCTU HSAD_MYCTU] Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9-DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate (DOHNAA) and 2-hydroxy-hexa-2,4-dienoate (HHD). Is also able to catalyze the hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) and the synthetic analog 8-(2-chlorophenyl)-2-hydroxy-5-methyl-6-oxoocta-2,4-dienoic acid (HOPODA).<ref>PMID:19875455</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 __TOC__
 </StructureSection>
-[[Category: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase]]
 [[Category: Large Structures]]
-[[Category: Myctu]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
-[[Category: Eltis, L D]]
+[[Category: Eltis LD]]
-[[Category: Lack, N]]
+[[Category: Lack N]]
-[[Category: Liu, J]]
+[[Category: Liu J]]
-[[Category: Lowe, E D]]
+[[Category: Lowe ED]]
-[[Category: Noble, M E.M]]
+[[Category: Noble MEM]]
-[[Category: Sim, E]]
+[[Category: Sim E]]
-[[Category: Westwood, I M]]
+[[Category: Westwood IM]]
-[[Category: Hsad]]
-[[Category: Hydrolase]]
-[[Category: Meta-cleavage product hydrolase]]
-[[Category: Serine hydrolase]]