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[[Image:2vdg.jpg|left|200px]]


{{Structure
==Barley Aldose Reductase 1 complex with butanol==
|PDB= 2vdg |SIZE=350|CAPTION= <scene name='initialview01'>2vdg</scene>, resolution 1.92&Aring;
<StructureSection load='2vdg' size='340' side='right'caption='[[2vdg]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Ndp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:1bo+Binding+Site+For+Chain+A'>AC5</scene> and <scene name='pdbsite=AC6:1bo+Binding+Site+For+Chain+A'>AC6</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene> and <scene name='pdbligand=1BO:1-BUTANOL'>1BO</scene>
<table><tr><td colspan='2'>[[2vdg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hordeum_vulgare Hordeum vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VDG FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1BO:1-BUTANOL'>1BO</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vdg OCA], [https://pdbe.org/2vdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vdg RCSB], [https://www.ebi.ac.uk/pdbsum/2vdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vdg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HORVU ALDR_HORVU]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vdg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vdg ConSurf].
<div style="clear:both"></div>


'''BARLEY ALDOSE REDUCTASE 1 COMPLEX WITH BUTANOL'''
==See Also==
 
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
In most higher plants a period of desiccation is the terminal event in embryogenesis. Excised barley embryos acquire desiccation tolerance at a precise developmental stage and cDNA clones have been isolated which are temporally linked with desiccation tolerance. One such clone (pG22-69) with a putative gene product of 34 kd displays high structural homology to mammalian genes encoding an NADPH dependent aldose reductase involved in the synthesis of sorbitol. This first aldose reductase gene of plants is expressed constitutively during embryo maturation and is modulated by the plant hormones abscisic acid (ABA) and gibberellic acid (GA). Immunohistochemistry showed that the protein is preferentially expressed in tissues formed at early stages in embryogenesis. Measurements of enzymatic activity indicate that pG22-69 encodes an active aldose reductase. The finding of this reductase activity and the cloning of the corresponding gene supports the existence of a metabolic pathway in plants playing a role in the synthesis of osmolytes like sorbitol. The significance of this work is that genes of related structure and functions are being used in diverse organisms to fulfil stress related biological requirements.
 
==About this Structure==
2VDG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hordeum_vulgare Hordeum vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDG OCA].
 
==Reference==
An ABA and GA modulated gene expressed in the barley embryo encodes an aldose reductase related protein., Bartels D, Engelhardt K, Roncarati R, Schneider K, Rotter M, Salamini F, EMBO J. 1991 May;10(5):1037-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1827067 1827067]
[[Category: Aldehyde reductase]]
[[Category: Hordeum vulgare]]
[[Category: Hordeum vulgare]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Christensen, C L.]]
[[Category: Christensen CL]]
[[Category: Henriksen, A.]]
[[Category: Henriksen A]]
[[Category: Olsen, J G.]]
[[Category: Olsen JG]]
[[Category: Olsen, O.]]
[[Category: Olsen O]]
[[Category: Pedersen, L.]]
[[Category: Pedersen L]]
[[Category: 1BO]]
[[Category: NDP]]
[[Category: SO4]]
[[Category: akr4c]]
[[Category: aldo-keto reductase]]
[[Category: aldose reductase]]
[[Category: ligand complex]]
[[Category: nadp]]
[[Category: oxidoreductase]]
[[Category: stress response]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:45:36 2008''

Latest revision as of 18:16, 13 December 2023

Barley Aldose Reductase 1 complex with butanolBarley Aldose Reductase 1 complex with butanol

Structural highlights

2vdg is a 1 chain structure with sequence from Hordeum vulgare. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.92Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALDR_HORVU

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2vdg, resolution 1.92Å

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OCA
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