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==beta-ketoacyl-ACP synthase I (KAS) from E. coli with bound inhibitor thiolactomycin==
==beta-ketoacyl-ACP synthase I (KAS) from E. coli with bound inhibitor thiolactomycin==
<StructureSection load='2vb8' size='340' side='right' caption='[[2vb8]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
<StructureSection load='2vb8' size='340' side='right'caption='[[2vb8]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vb8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VB8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VB8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.52&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f91|1f91]], [[1fj8|1fj8]], [[1g5x|1g5x]], [[1h4f|1h4f]], [[2aq7|2aq7]], [[2aqb|2aqb]], [[2buh|2buh]], [[2bui|2bui]], [[2byx|2byx]], [[2bz3|2bz3]], [[1dd8|1dd8]], [[1ek4|1ek4]], [[1fj4|1fj4]], [[2byw|2byw]], [[2byy|2byy]], [[2byz|2byz]], [[2bz4|2bz4]], [[2vb7|2vb7]], [[2vb9|2vb9]], [[2vba|2vba]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TLM:THIOLACTOMYCIN'>TLM</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_I Beta-ketoacyl-[acyl-carrier-protein] synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [https://pdbe.org/2vb8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [https://www.ebi.ac.uk/pdbsum/2vb8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb8 OCA], [http://pdbe.org/2vb8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vb8 RCSB], [http://www.ebi.ac.uk/pdbsum/2vb8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vb8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.  
[https://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Acyl carrier protein synthase|Acyl carrier protein synthase]]
*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Bailly, J]]
[[Category: Large Structures]]
[[Category: Hennig, M]]
[[Category: Bailly J]]
[[Category: Pappenberger, G]]
[[Category: Hennig M]]
[[Category: Schulz-Gasch, T]]
[[Category: Pappenberger G]]
[[Category: Acyltransferase]]
[[Category: Schulz-Gasch T]]
[[Category: Antibiotic]]
[[Category: Cytoplasm]]
[[Category: Fatty acid biosynthesis]]
[[Category: Fatty acid synthesis]]
[[Category: Lipid synthesis]]
[[Category: Thiolactomycin]]
[[Category: Transferase]]

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