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[[Image:2v90.gif|left|200px]]<br />
<applet load="2v90" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2v90, resolution 2.00&Aring;" />
'''CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF INTESTINE- AND KIDNEY-ENRICHED PDZ DOMAIN IKEPP (PDZD3)'''<br />


==About this Structure==
==Crystal structure of the 3rd PDZ domain of intestine- and kidney- enriched PDZ domain IKEPP (PDZD3)==
2V90 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V90 OCA].  
<StructureSection load='2v90' size='340' side='right'caption='[[2v90]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2v90]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V90 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v90 OCA], [https://pdbe.org/2v90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v90 RCSB], [https://www.ebi.ac.uk/pdbsum/2v90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v90 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NHRF4_HUMAN NHRF4_HUMAN] Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).<ref>PMID:11950846</ref> <ref>PMID:19088451</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v90_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v90 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Sodium-hydrogen exchange regulatory factor 3D structures|Sodium-hydrogen exchange regulatory factor 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.H.]]
[[Category: Arrowsmith CH]]
[[Category: Bunkoczi, G.]]
[[Category: Bunkoczi G]]
[[Category: Cooper, C.]]
[[Category: Cooper C]]
[[Category: Doyle, D.A.]]
[[Category: Doyle DA]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Elkins, J.]]
[[Category: Elkins J]]
[[Category: Gileadi, C.]]
[[Category: Gileadi C]]
[[Category: Phillips, C.]]
[[Category: Phillips C]]
[[Category: Pike, A.C.W.]]
[[Category: Pike ACW]]
[[Category: Salah, E.]]
[[Category: Salah E]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom M]]
[[Category: Ugochukwu, E.]]
[[Category: Ugochukwu E]]
[[Category: Uppenberg, J.]]
[[Category: Uppenberg J]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: SO4]]
[[Category: alternative splicing]]
[[Category: cytoplasm]]
[[Category: membrane]]
[[Category: pdz domain]]
[[Category: pdzd3]]
[[Category: protein-binding]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 14:17:28 2007''

Latest revision as of 18:10, 13 December 2023

Crystal structure of the 3rd PDZ domain of intestine- and kidney- enriched PDZ domain IKEPP (PDZD3)Crystal structure of the 3rd PDZ domain of intestine- and kidney- enriched PDZ domain IKEPP (PDZD3)

Structural highlights

2v90 is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NHRF4_HUMAN Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Scott RO, Thelin WR, Milgram SL. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. J Biol Chem. 2002 Jun 21;277(25):22934-41. PMID:11950846 doi:10.1074/jbc.M202434200
  2. ↑ Zachos NC, Hodson C, Kovbasnjuk O, Li X, Thelin WR, Cha B, Milgram S, Donowitz M. Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism. Cell Physiol Biochem. 2008;22(5-6):693-704. PMID:19088451 doi:10.1159/000185553

2v90, resolution 2.00Å

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