2v4u: Difference between revisions

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-[[Image:2v4u.png|left|200px]]
-{{STRUCTURE_2v4u|  PDB=2v4u  |  SCENE=  }}
+==Human CTP synthetase 2 - glutaminase domain in complex with 5-OXO-L- NORLEUCINE==
+<StructureSection load='2v4u' size='340' side='right'caption='[[2v4u]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-===HUMAN CTP SYNTHETASE 2 - GLUTAMINASE DOMAIN IN COMPLEX WITH 5-OXO-L-NORLEUCINE===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2v4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4U FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYD:2-AMINO-6-(CYSTEIN-S-YL)-5-OXO-HEXANOIC+ACID'>CYD</scene></td></tr>
-[[2v4u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4U OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4u OCA], [https://pdbe.org/2v4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4u RCSB], [https://www.ebi.ac.uk/pdbsum/2v4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4u ProSAT]</span></td></tr>
-[[Category: CTP synthase]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PYRG2_HUMAN PYRG2_HUMAN] Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.<ref>PMID:10899599</ref> <ref>PMID:16179339</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v4u_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v4u ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Andersson, J.]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Andersson J]]
-[[Category: Berg, S Van Den.]]
+[[Category: Arrowsmith CH]]
-[[Category: Berglund, H.]]
+[[Category: Berglund H]]
-[[Category: Collins, R.]]
+[[Category: Collins R]]
-[[Category: Dahlgren, L G.]]
+[[Category: Dahlgren LG]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards AM]]
-[[Category: Flodin, S.]]
+[[Category: Flodin S]]
-[[Category: Flores, A.]]
+[[Category: Flores A]]
-[[Category: Graslund, S.]]
+[[Category: Graslund S]]
-[[Category: Hammarstrom, M.]]
+[[Category: Hammarstrom M]]
-[[Category: Johansson, A.]]
+[[Category: Johansson A]]
-[[Category: Johansson, I.]]
+[[Category: Johansson I]]
-[[Category: Karlberg, T.]]
+[[Category: Karlberg T]]
-[[Category: Kotenyova, T.]]
+[[Category: Kotenyova T]]
-[[Category: Lehtio, L.]]
+[[Category: Lehtio L]]
-[[Category: Moche, M.]]
+[[Category: Moche M]]
-[[Category: Nilsson, M E.]]
+[[Category: Nilsson ME]]
-[[Category: Nordlund, P.]]
+[[Category: Nordlund P]]
-[[Category: Nyman, T.]]
+[[Category: Nyman T]]
-[[Category: Olesen, K.]]
+[[Category: Olesen K]]
-[[Category: Persson, C.]]
+[[Category: Persson C]]
-[[Category: Sagemark, J.]]
+[[Category: Sagemark J]]
-[[Category: Schueler, H.]]
+[[Category: Schueler H]]
-[[Category: Thorsell, A G.]]
+[[Category: Thorsell AG]]
-[[Category: Tresaugues, L.]]
+[[Category: Tresaugues L]]
-[[Category: Weigelt, J.]]
+[[Category: Van Den Berg S]]
-[[Category: Welin, M.]]
+[[Category: Weigelt J]]
-[[Category: Wikstrom, M.]]
+[[Category: Welin M]]
-[[Category: Wisniewska, M.]]
+[[Category: Wikstrom M]]
-[[Category: 5-oxo-l-norleucine]]
+[[Category: Wisniewska M]]
-[[Category: Ctp synthetase]]
-[[Category: Ctp]]
-[[Category: Cytidine 5'- triphosphate synthetase 2]]
-[[Category: Don]]
-[[Category: Glutaminase domain]]
-[[Category: Glutamine amidotransferase]]
-[[Category: Ligase]]
-[[Category: Nucleotide metabolism]]
-[[Category: Phosphoprotein]]
-[[Category: Pyrimidine biosynthesis]]
-[[Category: Utp-- ammonia ligase 2]]