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[[Image:2uz9.jpg|left|200px]]<br /><applet load="2uz9" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2uz9, resolution 2.30&Aring;" />
'''HUMAN GUANINE DEAMINASE (GUAD) IN COMPLEX WITH ZINC AND ITS PRODUCT XANTHINE.'''<br />


==Disease==
==Human guanine deaminase (guaD) in complex with zinc and its product Xanthine.==
Known diseases associated with this structure: Charcot-Marie-Tooth disease, mixed axonal and demyelinating type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606598 606598]], Charcot-Marie-Tooth disease, type 2G OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606598 606598]], Charcot-Marie-Tooth disease, type 2K OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606598 606598]], Charcot-Marie-Tooth disease, type 4A OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606598 606598]]
<StructureSection load='2uz9' size='340' side='right'caption='[[2uz9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2uz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZ9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XAN:XANTHINE'>XAN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz9 OCA], [https://pdbe.org/2uz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uz9 RCSB], [https://www.ebi.ac.uk/pdbsum/2uz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uz9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GUAD_HUMAN GUAD_HUMAN] Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uz9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uz9 ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
2UZ9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=XAN:'>XAN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Guanine_deaminase Guanine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.3 3.5.4.3] Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+1452'>AC1</scene> and <scene name='pdbsite=AC2:Xan+Binding+Site+For+Residue+A+1453'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ9 OCA].
*[[Deaminase 3D structures|Deaminase 3D structures]]
[[Category: Guanine deaminase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Berglund, H.]]
[[Category: Berglund H]]
[[Category: Busam, R.]]
[[Category: Busam R]]
[[Category: Collins, R.]]
[[Category: Collins R]]
[[Category: Dahlgren, L G.]]
[[Category: Dahlgren LG]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Flodin, S.]]
[[Category: Flodin S]]
[[Category: Flores, A.]]
[[Category: Flores A]]
[[Category: Graslund, S.]]
[[Category: Graslund S]]
[[Category: Hallberg, B M.]]
[[Category: Hallberg BM]]
[[Category: Hammarstrom, M.]]
[[Category: Hammarstrom M]]
[[Category: Holmberg-Schiavone, L.]]
[[Category: Holmberg-Schiavone L]]
[[Category: Johansson, I.]]
[[Category: Johansson I]]
[[Category: Kallas, A.]]
[[Category: Kallas A]]
[[Category: Karlberg, T.]]
[[Category: Karlberg T]]
[[Category: Kotenyova, T.]]
[[Category: Kotenyova T]]
[[Category: Lehtio, L.]]
[[Category: Lehtio L]]
[[Category: Moche, M.]]
[[Category: Moche M]]
[[Category: Nordlund, P.]]
[[Category: Nordlund P]]
[[Category: Nyman, T.]]
[[Category: Nyman T]]
[[Category: Ogg, D.]]
[[Category: Ogg D]]
[[Category: Persson, C.]]
[[Category: Persson C]]
[[Category: Sagemark, J.]]
[[Category: Sagemark J]]
[[Category: Sgc, Structural Genomics Consortium.]]
[[Category: Stenmark P]]
[[Category: Stenmark, P.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Thorsell AG]]
[[Category: Thorsell, A G.]]
[[Category: Weigelt J]]
[[Category: Van-Den-Berg, S.]]
[[Category: Welin M]]
[[Category: Weigelt, J.]]
[[Category: Van den berg S]]
[[Category: Welin, M.]]
[[Category: XAN]]
[[Category: ZN]]
[[Category: guanine aminohydrolase]]
[[Category: hydrolase]]
[[Category: purine metabolism]]
[[Category: zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:51:45 2008''

Latest revision as of 17:58, 13 December 2023

Human guanine deaminase (guaD) in complex with zinc and its product Xanthine.Human guanine deaminase (guaD) in complex with zinc and its product Xanthine.

Structural highlights

2uz9 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GUAD_HUMAN Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2uz9, resolution 2.30Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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