Proteopedia

2uv2: Difference between revisions

← Older edit
No edit summary
No edit summary
 
Line 3: Line 3:
<StructureSection load='2uv2' size='340' side='right'caption='[[2uv2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2uv2' size='340' side='right'caption='[[2uv2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2uv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ja0 2ja0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UV2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2uv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ja0 2ja0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UV2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GVD:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE'>GVD</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GVD:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE'>GVD</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2j51|2j51]], [[2ja0|2ja0]], [[2jfl|2jfl]], [[2jfm|2jfm]]</div></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uv2 OCA], [https://pdbe.org/2uv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uv2 RCSB], [https://www.ebi.ac.uk/pdbsum/2uv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uv2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uv2 OCA], [https://pdbe.org/2uv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uv2 RCSB], [https://www.ebi.ac.uk/pdbsum/2uv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uv2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SLK_HUMAN SLK_HUMAN] Mediates apoptosis and actin stress fiber dissolution.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 36: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H]]
[[Category: Bunkoczi G]]
[[Category: Bunkoczi, G]]
[[Category: Debreczeni JE]]
[[Category: Debreczeni, J E]]
[[Category: Edwards A]]
[[Category: Delft, F von]]
[[Category: Fedorov O]]
[[Category: Edwards, A]]
[[Category: Keates T]]
[[Category: Fedorov, O]]
[[Category: Knapp S]]
[[Category: Keates, T]]
[[Category: Papagrigoriou E]]
[[Category: Knapp, S]]
[[Category: Pike ACW]]
[[Category: Papagrigoriou, E]]
[[Category: Rellos P]]
[[Category: Pike, A C.W]]
[[Category: Salah E]]
[[Category: Rellos, P]]
[[Category: Savitsky P]]
[[Category: Salah, E]]
[[Category: Sundstrom M]]
[[Category: Savitsky, P]]
[[Category: Weigelt J]]
[[Category: Sundstrom, M]]
[[Category: Von Delft F]]
[[Category: Weigelt, J]]
[[Category: Apoptosis]]
[[Category: Atp-binding]]
[[Category: Germinal centre kinase]]
[[Category: Kinase]]
[[Category: Muscle development]]
[[Category: Nucleotide-binding]]
[[Category: Phosphorylation]]
[[Category: Serine- threonine kinase 2]]
[[Category: Serine-threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/w/2uv2"