2jk2: Difference between revisions
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<StructureSection load='2jk2' size='340' side='right'caption='[[2jk2]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2jk2' size='340' side='right'caption='[[2jk2]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2jk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JK2 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk2 OCA], [https://pdbe.org/2jk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jk2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk2 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk2 OCA], [https://pdbe.org/2jk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jk2 RCSB], [https://www.ebi.ac.uk/pdbsum/2jk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aguirre-Lopez B]] | |||
[[Category: Aguirre-Lopez | [[Category: Arreola-Alemon R]] | ||
[[Category: Arreola-Alemon | [[Category: Costas M]] | ||
[[Category: Costas | [[Category: De Gomez-Puyou MT]] | ||
[[Category: Gomez-Puyou | [[Category: Gomez-Puyou A]] | ||
[[Category: Gomez-Puyou | [[Category: Perez-Montfort R]] | ||
[[Category: Perez-Montfort | [[Category: Rodriguez-Almazan C]] | ||
[[Category: Rodriguez-Almazan | [[Category: Rodriguez-Larrea D]] | ||
[[Category: Rodriguez-Larrea | [[Category: Torres-Larios A]] | ||
[[Category: Torres-Larios | |||