2jhz: Difference between revisions

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 ==CRYSTAL STRUCTURE OF RHOGDI E155S, E157S MUTANT==
-<StructureSection load='2jhz' size='340' side='right' caption='[[2jhz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+<StructureSection load='2jhz' size='340' side='right'caption='[[2jhz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2jhz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JHZ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2jhz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JHZ FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cc0|1cc0]], [[1fso|1fso]], [[1fst|1fst]], [[1ft0|1ft0]], [[1ft3|1ft3]], [[1hh4|1hh4]], [[1kmt|1kmt]], [[1qvy|1qvy]], [[1rho|1rho]], [[2bxw|2bxw]], [[2jhs|2jhs]], [[2jht|2jht]], [[2jhu|2jhu]], [[2jhv|2jhv]], [[2jhw|2jhw]], [[2jhx|2jhx]], [[2jhy|2jhy]], [[2ji0|2ji0]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jhz RCSB], [http://www.ebi.ac.uk/pdbsum/2jhz PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhz OCA], [https://pdbe.org/2jhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jhz RCSB], [https://www.ebi.ac.uk/pdbsum/2jhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhz ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/GDIR1_HUMAN GDIR1_HUMAN] Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhz_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhz_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jhz ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 24: / Line 27: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2jhz" style="background-color:#fffaf0;"></div>
 ==See Also==
@@ Line 32: / Line 36: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Cooper, D R]]
+[[Category: Large Structures]]
-[[Category: Derewenda, Z S]]
+[[Category: Cooper DR]]
-[[Category: Pinkowska, M]]
+[[Category: Derewenda ZS]]
-[[Category: Crystal engineering]]
+[[Category: Pinkowska M]]
-[[Category: Gtpase activation]]
-[[Category: Inhibitor]]
-[[Category: Surface entropy reduction]]