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==3D STRUCTURE OF LUMAZINE SYNTHASE FROM CANDIDA ALBICANS==
 
<StructureSection load='2jfb' size='340' side='right' caption='[[2jfb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
==3D Structure of Lumazine Synthase from Candida albicans==
<StructureSection load='2jfb' size='340' side='right'caption='[[2jfb]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jfb]] is a 15 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFB OCA]. <br>
<table><tr><td colspan='2'>[[2jfb]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JFB FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jfb RCSB], [http://www.ebi.ac.uk/pdbsum/2jfb PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfb OCA], [https://pdbe.org/2jfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jfb RCSB], [https://www.ebi.ac.uk/pdbsum/2jfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jfb ProSAT]</span></td></tr>
<table>
</table>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/2jfb_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/2jfb_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jfb ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design.,Morgunova E, Saller S, Haase I, Cushman M, Bacher A, Fischer M, Ladenstein R J Biol Chem. 2007 Jun 8;282(23):17231-41. Epub 2007 Apr 18. PMID:17446177<ref>PMID:17446177</ref>
Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design.,Morgunova E, Saller S, Haase I, Cushman M, Bacher A, Fischer M, Ladenstein R J Biol Chem. 2007 Jun 8;282(23):17231-41. Epub 2007 Apr 18. PMID:17446177<ref>PMID:17446177</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2jfb" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Candida albicans]]
[[Category: Candida albicans]]
[[Category: Riboflavin synthase]]
[[Category: Large Structures]]
[[Category: Bacher, A.]]
[[Category: Bacher A]]
[[Category: Cushman, M.]]
[[Category: Cushman M]]
[[Category: Fischer, M.]]
[[Category: Fischer M]]
[[Category: Ladenstein, R.]]
[[Category: Ladenstein R]]
[[Category: Morgunova, E.]]
[[Category: Morgunova E]]
[[Category: Candida albican]]
[[Category: Lumazine synthase]]
[[Category: Riboflavin biosynthesis]]
[[Category: Transferase]]

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