2j5y: Difference between revisions
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== | ==Crystal structure of the GA module from F.magna== | ||
The albumin-binding domain, or GA module, of the peptostreptococcal | <StructureSection load='2j5y' size='340' side='right'caption='[[2j5y]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2j5y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Finegoldia_magna Finegoldia magna]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J5Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5y OCA], [https://pdbe.org/2j5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j5y RCSB], [https://www.ebi.ac.uk/pdbsum/2j5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j5y ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PAB_FINMA PAB_FINMA] Binds serum albumin. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j5/2j5y_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j5y ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The albumin-binding domain, or GA module, of the peptostreptococcal albumin-binding protein expressed in pathogenic strains of Finegoldia magna is believed to be responsible for the virulence and increased growth rate of these strains. Here we present the 1.4A crystal structure of this domain, and compare it with the crystal structure of the GA-albumin complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA module is "sticky", and is capable of forming contacts with a range of protein surfaces. This might lead to interactions with different host proteins. | |||
Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution.,Cramer JF, Nordberg PA, Hajdu J, Lejon S FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:17575979<ref>PMID:17575979</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2j5y" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Finegoldia magna]] | [[Category: Finegoldia magna]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Cramer | [[Category: Cramer JF]] | ||
[[Category: Lejon | [[Category: Lejon S]] | ||
[[Category: Lundqvist | [[Category: Lundqvist T]] | ||
[[Category: Nordberg | [[Category: Nordberg PA]] | ||
[[Category: Valegard | [[Category: Valegard K]] | ||