2iwm: Difference between revisions

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-{{Seed}}
-[[Image:2iwm.png|left|200px]]
-<!--
+==precursor mutant Cys1Ser of Penicillin V Acylase from Bacillus sphaericus==
-The line below this paragraph, containing "STRUCTURE_2iwm", creates the "Structure Box" on the page.
+<StructureSection load='2iwm' size='340' side='right'caption='[[2iwm]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2iwm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IWM FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwm OCA], [https://pdbe.org/2iwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iwm RCSB], [https://www.ebi.ac.uk/pdbsum/2iwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iwm ProSAT]</span></td></tr>
-{{STRUCTURE_2iwm|  PDB=2iwm  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PAC_LYSSH PAC_LYSSH] The enzyme catalyzes the conversion of penicillin to 6-aminopenicillanate The precursor, furthermore, acts as a self-processing peptidase that cleaves off the propeptide. All peptidase activity is lost on conversion to the mature peptidase.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iwm_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iwm ConSurf].
+<div style="clear:both"></div>
-===PRECURSOR MUTANT CYS1SER OF PENICILLIN V ACYLASE FROM BACILLUS SPHAERICUS===
+==See Also==
+*[[Penicillin acylase|Penicillin acylase]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_16508111}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16508111 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_16508111}}
-==About this Structure==
-IWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lysinibacillus_sphaericus Lysinibacillus sphaericus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWM OCA].
-==Reference==
-Cloning, preparation and preliminary crystallographic studies of penicillin V acylase autoproteolytic processing mutants., Chandra PM, Brannigan JA, Prabhune A, Pundle A, Turkenburg JP, Dodson GG, Suresh CG, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jan 1;61(Pt, 1):124-7. Epub 2004 Dec 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16508111 16508111]
 [[Category: Lysinibacillus sphaericus]]
-[[Category: Penicillin amidase]]
+[[Category: Chandra PM]]
-[[Category: Single protein]]
+[[Category: Dodson G]]
-[[Category: Chandra, P M.]]
+[[Category: Suresh CG]]
-[[Category: Dodson, G.]]
-[[Category: Suresh, C G.]]
-[[Category: Antibiotic resistance]]
-[[Category: Autoproteolysis]]
-[[Category: Hydrolase]]
-[[Category: Penicillin]]
-[[Category: Precursor]]
-[[Category: Zymogen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:15:41 2008''