2cmw: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2cmw.gif|left|200px]]<br />
-<applet load="2cmw" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2cmw, resolution 1.75&Aring;" />
-'''STRUCTURE OF HUMAN CASEIN KINASE 1 GAMMA-1 IN COMPLEX WITH 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE (CASP TARGET)'''<br />
-==About this Structure==
+==Structure of Human Casein kinase 1 gamma-1 in complex with 2-(2- Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine==
-CMW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with PO4, ACT and OLP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CMW OCA]].
+<StructureSection load='2cmw' size='340' side='right'caption='[[2cmw]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2cmw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CMW FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=OLP:2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE'>OLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SCS:3-(ETHYLDISULFANYL)-L-ALANINE'>SCS</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmw OCA], [https://pdbe.org/2cmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cmw RCSB], [https://www.ebi.ac.uk/pdbsum/2cmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KC1G1_HUMAN KC1G1_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.<ref>PMID:21680713</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cmw_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cmw ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Casein kinase 3D structures|Casein kinase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith C]]
-[[Category: Bunkoczi, G.]]
+[[Category: Bunkoczi G]]
-[[Category: Das, S.]]
+[[Category: Das S]]
-[[Category: Delft, F.Von.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Fedorov O]]
-[[Category: Fedorov, O.]]
+[[Category: Knapp S]]
-[[Category: Knapp, S.]]
+[[Category: Niesen F]]
-[[Category: Niesen, F.]]
+[[Category: Pike ACW]]
-[[Category: Pike, A.C.W.]]
+[[Category: Rellos P]]
-[[Category: Rellos, P.]]
+[[Category: Savitsky P]]
-[[Category: Savitsky, P.]]
+[[Category: Sobott F]]
-[[Category: Sobott, F.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Von Delft F]]
-[[Category: ACT]]
-[[Category: OLP]]
-[[Category: PO4]]
-[[Category: alternative splicing]]
-[[Category: atp-binding]]
-[[Category: kinase]]
-[[Category: nucleotide-binding]]
-[[Category: phosphorylation]]
-[[Category: serine/threonine protein kinase]]
-[[Category: serine/threonine-protein kinase]]
-[[Category: transferase]]
-[[Category: wnt signaling pathway]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:13:00 2007''