2cbu: Difference between revisions

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[[Image:2cbu.gif|left|200px]]


{{Structure
==Beta-glucosidase from Thermotoga maritima in complex with castanospermine==
|PDB= 2cbu |SIZE=350|CAPTION= <scene name='initialview01'>2cbu</scene>, resolution 1.85&Aring;
<StructureSection load='2cbu' size='340' side='right'caption='[[2cbu]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
|SITE= <scene name='pdbsite=NUC:Ca+Binding+Site+For+Chain+B'>NUC</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CTS:CASTANOSPERMINE'>CTS</scene>
<table><tr><td colspan='2'>[[2cbu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CBU FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CTS:CASTANOSPERMINE'>CTS</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cbu OCA], [https://pdbe.org/2cbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cbu RCSB], [https://www.ebi.ac.uk/pdbsum/2cbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cbu ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cbu OCA], [http://www.ebi.ac.uk/pdbsum/2cbu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cbu RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/BGLA_THEMA BGLA_THEMA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/2cbu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cbu ConSurf].
<div style="clear:both"></div>


'''BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH CASTANOSPERMINE'''
==See Also==
 
*[[Beta-glucosidase 3D structures|Beta-glucosidase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2CBU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CBU OCA].
[[Category: Large Structures]]
 
==Reference==
Dissection of conformationally restricted inhibitors binding to a beta-glucosidase., Gloster TM, Madsen R, Davies GJ, Chembiochem. 2006 May;7(5):738-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16628756 16628756]
[[Category: Beta-glucosidase]]
[[Category: Single protein]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Davies, G J.]]
[[Category: Davies GJ]]
[[Category: Gloster, T M.]]
[[Category: Gloster TM]]
[[Category: Madsen, R.]]
[[Category: Madsen R]]
[[Category: carbohydrate metabolism]]
[[Category: cellulose degradation]]
[[Category: family 1]]
[[Category: glycosidase]]
[[Category: glycoside hydrolase]]
[[Category: hydrolase]]
[[Category: inhibitor]]
[[Category: polysaccharide degradation]]
[[Category: transition state mimic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:19:22 2008''

Latest revision as of 17:12, 13 December 2023

Beta-glucosidase from Thermotoga maritima in complex with castanospermineBeta-glucosidase from Thermotoga maritima in complex with castanospermine

Structural highlights

2cbu is a 2 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.85Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BGLA_THEMA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2cbu, resolution 1.85Å

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OCA
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