2cbu: Difference between revisions

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[[Image:2cbu.gif|left|200px]]<br />
<applet load="2cbu" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2cbu, resolution 1.85&Aring;" />
'''BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH CASTANOSPERMINE'''<br />


==About this Structure==
==Beta-glucosidase from Thermotoga maritima in complex with castanospermine==
2CBU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with ACT, CA and CTS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21]]. Structure known Active Site: NUC. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CBU OCA]].  
<StructureSection load='2cbu' size='340' side='right'caption='[[2cbu]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2cbu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CBU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CTS:CASTANOSPERMINE'>CTS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cbu OCA], [https://pdbe.org/2cbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cbu RCSB], [https://www.ebi.ac.uk/pdbsum/2cbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cbu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BGLA_THEMA BGLA_THEMA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/2cbu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cbu ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
Dissection of conformationally restricted inhibitors binding to a beta-glucosidase., Gloster TM, Madsen R, Davies GJ, Chembiochem. 2006 May;7(5):738-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16628756 16628756]
*[[Beta-glucosidase 3D structures|Beta-glucosidase 3D structures]]
[[Category: Beta-glucosidase]]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Davies, G.J.]]
[[Category: Davies GJ]]
[[Category: Gloster, T.M.]]
[[Category: Gloster TM]]
[[Category: Madsen, R.]]
[[Category: Madsen R]]
[[Category: ACT]]
[[Category: CA]]
[[Category: CTS]]
[[Category: carbohydrate metabolism]]
[[Category: cellulose degradation]]
[[Category: family 1]]
[[Category: glycosidase]]
[[Category: glycoside hydrolase]]
[[Category: hydrolase]]
[[Category: inhibitor]]
[[Category: polysaccharide degradation]]
[[Category: transition state mimic]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:00:18 2007''

Latest revision as of 17:12, 13 December 2023

Beta-glucosidase from Thermotoga maritima in complex with castanospermineBeta-glucosidase from Thermotoga maritima in complex with castanospermine

Structural highlights

2cbu is a 2 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.85Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BGLA_THEMA

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2cbu, resolution 1.85Å

Drag the structure with the mouse to rotate

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OCA
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