2cb1: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2cb1.png|left|200px]]


<!--
==Crystal Structure of O-actetyl Homoserine Sulfhydrylase From Thermus Thermophilus HB8,OAH2.==
The line below this paragraph, containing "STRUCTURE_2cb1", creates the "Structure Box" on the page.
<StructureSection load='2cb1' size='340' side='right'caption='[[2cb1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2cb1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CB1 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
{{STRUCTURE_2cb1|  PDB=2cb1 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cb1 OCA], [https://pdbe.org/2cb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cb1 RCSB], [https://www.ebi.ac.uk/pdbsum/2cb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cb1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cb1 TOPSAN]</span></td></tr>
 
</table>
===CRYSTAL STRUCTURE OF O-ACTETYL HOMOSERINE SULFHYDRYLASE FROM THERMUS THERMOPHILUS HB8,OAH2.===
== Function ==
 
[https://www.uniprot.org/uniprot/METY2_THET8 METY2_THET8] Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway. Has weak activity with O-acetyl-L-serine, O-phospho-L-serine, L-serine, O-succinyl-L-homoserine and L-homoserine. Shows a very low CTT gamma-synthase activity.<ref>PMID:15215603</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2CB1 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CB1 OCA].  
Check<jmol>
[[Category: O-acetylhomoserine aminocarboxypropyltransferase]]
  <jmolCheckbox>
[[Category: Thermus thermophilus]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/2cb1_consurf.spt"</scriptWhenChecked>
[[Category: Agari, Y.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Ebihara, A.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Imagawa, T.]]
  </jmolCheckbox>
[[Category: Kanagawa, M.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cb1 ConSurf].
[[Category: Kuramitsu, S.]]
<div style="clear:both"></div>
[[Category: Kuroishi, C.]]
== References ==
[[Category: Nakagawa, N.]]
<references/>
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
__TOC__
[[Category: Tsuge, H.]]
</StructureSection>
[[Category: Utsunomiya, H.]]
[[Category: Large Structures]]
[[Category: Yokoyama, S.]]
[[Category: Thermus thermophilus HB8]]
[[Category: Homoserine]]
[[Category: Agari Y]]
[[Category: Lyase]]
[[Category: Ebihara A]]
[[Category: Plp enzyme]]
[[Category: Imagawa T]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Kanagawa M]]
[[Category: Rsgi]]
[[Category: Kuramitsu S]]
[[Category: Structural genomic]]
[[Category: Kuroishi C]]
[[Category: Sulfhydrylase]]
[[Category: Nakagawa N]]
 
[[Category: Tsuge H]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 10:04:44 2008''
[[Category: Utsunomiya H]]
[[Category: Yokoyama S]]

Latest revision as of 17:11, 13 December 2023

Crystal Structure of O-actetyl Homoserine Sulfhydrylase From Thermus Thermophilus HB8,OAH2.Crystal Structure of O-actetyl Homoserine Sulfhydrylase From Thermus Thermophilus HB8,OAH2.

Structural highlights

2cb1 is a 1 chain structure with sequence from Thermus thermophilus HB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

METY2_THET8 Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway. Has weak activity with O-acetyl-L-serine, O-phospho-L-serine, L-serine, O-succinyl-L-homoserine and L-homoserine. Shows a very low CTT gamma-synthase activity.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Iwama T, Hosokawa H, Lin W, Shimizu H, Kawai K, Yamagata S. Comparative characterization of the oah2 gene homologous to the oah1 of Thermus thermophilus HB8. Biosci Biotechnol Biochem. 2004 Jun;68(6):1357-61. PMID:15215603 doi:10.1271/bbb.68.1357

2cb1, resolution 2.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2cb1&oldid=3984833"