2ca0: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:2ca0.gif|left|200px]]<br /><applet load="2ca0" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2ca0, resolution 2.85&Aring;" />
-'''CRYSTAL STRUCTURE OF YC-17-BOUND CYTOCHROME P450 PIKC (CYP107L1)'''<br />
-==About this Structure==
+==Crystal structure of YC-17-bound cytochrome P450 PikC (CYP107L1)==
-CA0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae] with <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=PXI:'>PXI</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Pxi+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA0 OCA].
+<StructureSection load='2ca0' size='340' side='right'caption='[[2ca0]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
-[[Category: Single protein]]
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ca0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CA0 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PXI:4-{[4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY}-12-ETHYL-3,5,7,11-TETRAMETHYLOXACYCLODODEC-9-ENE-2,8-DIONE'>PXI</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ca0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca0 OCA], [https://pdbe.org/2ca0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ca0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ca0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PIKC_STRVZ PIKC_STRVZ] Catalyzes the hydroxylation of narbomycin to give rise to pikromycin, and of 10-deoxymethymycin (YC-17) to give rise to methymycin and neomethymycin during macrolide antibiotic biosynthesis. In addition, produces low amounts of neopicromycin, novapikromycin and novamethymycin. Requires the participation of a ferredoxin and a ferredoxin reductase for the transfer of electrons from NADPH to the monooxygenase.<ref>PMID:16825192</ref> <ref>PMID:19124459</ref> <ref>PMID:19833867</ref> <ref>PMID:24627965</ref> <ref>PMID:9778370</ref> <ref>PMID:9831532</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/2ca0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ca0 ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
+*[[Cytochrome P450 hydroxylase 3D structures|Cytochrome P450 hydroxylase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Streptomyces venezuelae]]
-[[Category: Kim, Y.]]
+[[Category: Kim Y]]
-[[Category: Podust, L M.]]
+[[Category: Podust LM]]
-[[Category: Sherman, D H.]]
+[[Category: Sherman DH]]
-[[Category: Waterman, M R.]]
+[[Category: Waterman MR]]
-[[Category: Yermalitskaya, L I.]]
+[[Category: Yermalitskaya LI]]
-[[Category: HEM]]
-[[Category: PXI]]
-[[Category: antibiotic biosynthesis]]
-[[Category: cytochrome p450]]
-[[Category: heme]]
-[[Category: iron]]
-[[Category: macrolide monooxygenase]]
-[[Category: metal-binding]]
-[[Category: oxidoreductase]]
-[[Category: pikc]]
-[[Category: yc-17]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:46:31 2008''