2c9t: Difference between revisions

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 <StructureSection load='2c9t' size='340' side='right'caption='[[2c9t]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2c9t]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica] and [http://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C9T FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2c9t]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica] and [https://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C9T FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cnl|1cnl]], [[1e74|1e74]], [[1e75|1e75]], [[1e76|1e76]], [[1g2g|1g2g]], [[1im1|1im1]], [[1imi|1imi]], [[2br7|2br7]], [[2br8|2br8]], [[2byn|2byn]], [[2byp|2byp]], [[2byq|2byq]], [[2byr|2byr]], [[2bys|2bys]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c9t OCA], [http://pdbe.org/2c9t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c9t RCSB], [http://www.ebi.ac.uk/pdbsum/2c9t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c9t ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c9t OCA], [https://pdbe.org/2c9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c9t RCSB], [https://www.ebi.ac.uk/pdbsum/2c9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c9t ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CA1_CONIM CA1_CONIM]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref>
+[https://www.uniprot.org/uniprot/Q8WSF8_APLCA Q8WSF8_APLCA]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 [[Category: Conus imperialis]]
 [[Category: Large Structures]]
-[[Category: Bertrand, D]]
+[[Category: Bertrand D]]
-[[Category: Celie, P H]]
+[[Category: Celie PH]]
-[[Category: Hogg, R C]]
+[[Category: Hogg RC]]
-[[Category: Sixma, T K]]
+[[Category: Sixma TK]]
-[[Category: Smit, A B]]
+[[Category: Smit AB]]
-[[Category: Tsetlin, V]]
+[[Category: Tsetlin V]]
-[[Category: Ulens, C]]
+[[Category: Ulens C]]
-[[Category: Acetylcholine binding protein]]
-[[Category: Acetylcholine receptor inhibitor]]
-[[Category: Amidation]]
-[[Category: Conformational flexibility]]
-[[Category: Conotoxin]]
-[[Category: Neurotoxin]]
-[[Category: Nicotinic acetylcholine receptor-toxin complex]]
-[[Category: Postsynaptic neurotoxin]]
-[[Category: Receptor-toxin complex]]
-[[Category: Receptor/toxin]]
-[[Category: Toxin]]