2c9h: Difference between revisions

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-[[Image:2c9h.gif|left|200px]]<br />
-<applet load="2c9h" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2c9h, resolution 1.80&Aring;" />
-'''STRUCTURE OF MITOCHONDRIAL BETA-KETOACYL SYNTHASE'''<br />
-==About this Structure==
+==Structure of mitochondrial beta-ketoacyl synthase==
-C9H is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NI as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C9H OCA]].
+<StructureSection load='2c9h' size='340' side='right'caption='[[2c9h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2c9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C9H FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c9h OCA], [https://pdbe.org/2c9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c9h RCSB], [https://www.ebi.ac.uk/pdbsum/2c9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c9h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/OXSM_HUMAN OXSM_HUMAN] May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.<ref>PMID:15668256</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/2c9h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c9h ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith C]]
-[[Category: Bunkoczi, G.]]
+[[Category: Bunkoczi G]]
-[[Category: Delft, F.Von.]]
+[[Category: Edwards A]]
-[[Category: Edwards, A.]]
+[[Category: Gileadi O]]
-[[Category: Gileadi, O.]]
+[[Category: Oppermann U]]
-[[Category: Oppermann, U.]]
+[[Category: Smee C]]
-[[Category: Smee, C.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Wu X]]
-[[Category: Wu, X.]]
+[[Category: Von Delft F]]
-[[Category: NI]]
-[[Category: fatty acid synthesis]]
-[[Category: ketoacyl synthase]]
-[[Category: mitochondria]]
-[[Category: transferase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:04:37 2007''