2c94: Difference between revisions

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<StructureSection load='2c94' size='340' side='right'caption='[[2c94]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2c94' size='340' side='right'caption='[[2c94]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2c94]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C94 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2c94]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C94 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TSF:3-(1,3,7-TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL)+1,1+DIFLUOROPENTANE-1-PHOSPHATE'>TSF</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w19|1w19]], [[1w29|1w29]], [[2c92|2c92]], [[2c97|2c97]], [[2c9b|2c9b]], [[2c9d|2c9d]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TSF:3-(1,3,7-TRIHYDRO-9-D-RIBITYL-2,6,8-PURINETRIONE-7-YL)+1,1+DIFLUOROPENTANE-1-PHOSPHATE'>TSF</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c94 OCA], [https://pdbe.org/2c94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c94 RCSB], [https://www.ebi.ac.uk/pdbsum/2c94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c94 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c94 OCA], [http://pdbe.org/2c94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c94 RCSB], [http://www.ebi.ac.uk/pdbsum/2c94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c94 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RISB_MYCTU RISB_MYCTU]] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:15723519</ref>
[https://www.uniprot.org/uniprot/RISB_MYCTU RISB_MYCTU] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:15723519</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Riboflavin synthase]]
[[Category: Bacher, A]]
[[Category: Cushman, M]]
[[Category: Fischer, M]]
[[Category: Haase, I]]
[[Category: Illarionov, B]]
[[Category: Jin, G]]
[[Category: Ladenstein, R]]
[[Category: Morgunova, E]]
[[Category: Inhibitor binding]]
[[Category: Lumazine synthase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Riboflavin biosynthesis]]
[[Category: Bacher A]]
[[Category: Transferase]]
[[Category: Cushman M]]
[[Category: Fischer M]]
[[Category: Haase I]]
[[Category: Illarionov B]]
[[Category: Jin G]]
[[Category: Ladenstein R]]
[[Category: Morgunova E]]

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