2c7v: Difference between revisions

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<StructureSection load='2c7v' size='340' side='right'caption='[[2c7v]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2c7v' size='340' side='right'caption='[[2c7v]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2c7v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C7V FirstGlance]. <br>
<table><tr><td colspan='2'>[[2c7v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C7V FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CAF:S-DIMETHYLARSINOYL-CYSTEINE'>CAF</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7v OCA], [https://pdbe.org/2c7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c7v RCSB], [https://www.ebi.ac.uk/pdbsum/2c7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7v OCA], [https://pdbe.org/2c7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c7v RCSB], [https://www.ebi.ac.uk/pdbsum/2c7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O76290_TRYBB O76290_TRYBB]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pteridine reductase]]
[[Category: Trypanosoma brucei brucei]]
[[Category: Trybb]]
[[Category: Dawson A]]
[[Category: Dawson, A]]
[[Category: Fairlamb AH]]
[[Category: Fairlamb, A H]]
[[Category: Fyfe PK]]
[[Category: Fyfe, P K]]
[[Category: Gibellini F]]
[[Category: Gibellini, F]]
[[Category: Hunter WN]]
[[Category: Hunter, W N]]
[[Category: McLuskey K]]
[[Category: McLuskey, K]]
[[Category: Sienkiewicz N]]
[[Category: Sienkiewicz, N]]
[[Category: Drug resistance]]
[[Category: Methotrexate resistance]]
[[Category: Oxidoreductase]]
[[Category: Short-chain dehydrogenase/reductase]]
[[Category: Trypanosomatid]]

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