2c4p: Difference between revisions

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 ==Crystal structure of human ubiquitin-conjugating enzyme UbcH5A==
-<StructureSection load='2c4p' size='340' side='right' caption='[[2c4p]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
+<StructureSection load='2c4p' size='340' side='right'caption='[[2c4p]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2c4p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C4P FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2c4p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C4P FirstGlance]. <br>
-</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c4p OCA], [http://pdbe.org/2c4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c4p RCSB], [http://www.ebi.ac.uk/pdbsum/2c4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c4p ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c4p OCA], [https://pdbe.org/2c4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c4p RCSB], [https://www.ebi.ac.uk/pdbsum/2c4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c4p ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/UB2D1_HUMAN UB2D1_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.<ref>PMID:18042044</ref> <ref>PMID:18359941</ref> <ref>PMID:19103148</ref> <ref>PMID:19854139</ref> <ref>PMID:20061386</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 ==See Also==
-*[[Ubiquitin conjugating enzyme|Ubiquitin conjugating enzyme]]
+*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Ubiquitin--protein ligase]]
+[[Category: Large Structures]]
-[[Category: Dodd, R B]]
+[[Category: Dodd RB]]
-[[Category: Read, R J]]
+[[Category: Read RJ]]
-[[Category: Ligase]]
-[[Category: Thioesterification]]
-[[Category: Ubiquitin-conjugating enzyme]]
-[[Category: Ubl conjugation pathway]]