2c46: Difference between revisions
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== | ==CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase== | ||
<StructureSection load='2c46' size='340' side='right'caption='[[2c46]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2c46]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C46 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c46 OCA], [https://pdbe.org/2c46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c46 RCSB], [https://www.ebi.ac.uk/pdbsum/2c46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c46 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MCE1_HUMAN MCE1_HUMAN] Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c46_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c46 ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith C]] | |||
[[Category: Arrowsmith | [[Category: Bunkoczi G]] | ||
[[Category: Bunkoczi | [[Category: Debreczeni J]] | ||
[[Category: Debreczeni | [[Category: Edwards A]] | ||
[[Category: Gileadi O]] | |||
[[Category: Edwards | [[Category: Johansson C]] | ||
[[Category: Gileadi | [[Category: Knapp S]] | ||
[[Category: Johansson | [[Category: Longman E]] | ||
[[Category: Knapp | [[Category: SavitskySmee P]] | ||
[[Category: Longman | [[Category: Smee C]] | ||
[[Category: | [[Category: Sundstrom M]] | ||
[[Category: Smee | [[Category: Ugochukwu E]] | ||
[[Category: Sundstrom | [[Category: Weigelt J]] | ||
[[Category: Ugochukwu | [[Category: Von Delft F]] | ||
[[Category: Weigelt | |||
[[Category: | |||
Latest revision as of 17:05, 13 December 2023
CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphataseCRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase
Structural highlights
FunctionMCE1_HUMAN Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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