2c2x: Difference between revisions

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-[[Image:2c2x.png|left|200px]]
-<!--
+==Three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Mycobacterium tuberculosis==
-The line below this paragraph, containing "STRUCTURE_2c2x", creates the "Structure Box" on the page.
+<StructureSection load='2c2x' size='340' side='right'caption='[[2c2x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2c2x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2X FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2x OCA], [https://pdbe.org/2c2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c2x RCSB], [https://www.ebi.ac.uk/pdbsum/2c2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2x ProSAT], [https://www.topsan.org/Proteins/TBSGC/2c2x TOPSAN]</span></td></tr>
-{{STRUCTURE_2c2x|  PDB=2c2x  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FOLD_MYCTU FOLD_MYCTU] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.[HAMAP-Rule:MF_01576]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2x_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c2x ConSurf].
+<div style="clear:both"></div>
-===THREE DIMENSIONAL STRUCTURE OF BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE-CYCLOHYDROLASE FROM MYCOBACTERIUM TUBERCULOSIS===
+==See Also==
+*[[Cyclohydrolase 3D structures|Cyclohydrolase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[2c2x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2X OCA].
+[[Category: Large Structures]]
-[[Category: Mycobacterium tuberculosis]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
-[[Category: Javid-Majd, F.]]
+[[Category: Javid-Majd F]]
-[[Category: Sacchettini, J C.]]
+[[Category: Sacchettini JC]]
-[[Category: Tbsgc, Tb Structural Genomics Consortium.]]
-[[Category: Cyclohydrolase]]
-[[Category: Hydrolase]]
-[[Category: Methylenetetrahydrofolate dehydrogenase]]
-[[Category: Nadp]]
-[[Category: Oxidoreductase]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Tb structural genomics consortium]]
-[[Category: Tbsgc]]
-[[Category: Tetrahydrofolate]]