2c2w: Difference between revisions

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-[[Image:2c2w.gif|left|200px]]<br />
-<applet load="2c2w" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2c2w, resolution 2.00&Aring;" />
-'''THE FLUORINASE FROM STREPTOMYCES CATTLEYA IS ALSO A CHLORINASE. STRUCTURE OF 5'-CHLORO-5'-DEOXYADENOSINE CRYSTALLISED IN THE FLUORINASE.'''<br />
-==About this Structure==
+==The fluorinase from Streptomyces cattleya is also a chlorinase. Structure of 5'-chloro-5'-deoxyadenosine crystallised in the fluorinase.==
-C2W is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]] with CL and 5CD as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Adenosyl-fluoride_synthase Adenosyl-fluoride synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.63 2.5.1.63]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C2W OCA]].
+<StructureSection load='2c2w' size='340' side='right'caption='[[2c2w]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
-==Reference==
+<table><tr><td colspan='2'>[[2c2w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2W FirstGlance]. <br>
-The fluorinase from Streptomyces cattleya is also a chlorinase., Deng H, Cobb SL, McEwan AR, McGlinchey RP, Naismith JH, O'Hagan D, Robinson DA, Spencer JB, Angew Chem Int Ed Engl. 2006 Jan 23;45(5):759-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16370017 16370017]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-[[Category: Adenosyl-fluoride synthase]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CD:5-CHLORO-5-DEOXYADENOSINE'>5CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-[[Category: Single protein]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2w OCA], [https://pdbe.org/2c2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c2w RCSB], [https://www.ebi.ac.uk/pdbsum/2c2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2w ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FLA_STRCT FLA_STRCT] Involved in the biosynthesis of fluorometabolites. Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'-deoxyadenosine in place of adenosine as substrate.<ref>PMID:12860396</ref> <ref>PMID:14765200</ref> <ref>PMID:16370017</ref> <ref>PMID:16604208</ref> <ref>PMID:16720268</ref> <ref>PMID:17985882</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2w_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c2w ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Streptomyces cattleya]]
-[[Category: Hagan, D.O.]]
+[[Category: McEwan AR]]
-[[Category: Mcewan, A.R.]]
+[[Category: Naismith JH]]
-[[Category: Naismith, J.H.]]
+[[Category: O'Hagan D]]
-[[Category: 5CD]]
-[[Category: CL]]
-[[Category: 5'-chloro-5'-deoxyadenosine]]
-[[Category: bacterial chlorinating enzyme]]
-[[Category: bacterial fluorinating enzyme]]
-[[Category: chlorinase]]
-[[Category: fla]]
-[[Category: fluorinase]]
-[[Category: streptomyces cattleya]]
-[[Category: transferase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:56:04 2007''