2c27: Difference between revisions

No edit summary
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:


==The structure of Mycothiol Synthase in complex with des- AcetylMycothiol and CoenzymeA.==
==The Structure of Mycothiol Synthase in Complex with des- AcetylMycothiol and CoenzymeA.==
<StructureSection load='2c27' size='340' side='right' caption='[[2c27]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2c27' size='340' side='right'caption='[[2c27]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C27 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2c27]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C27 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ozp|1ozp]], [[1p0h|1p0h]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MA8:(2S,3R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL+2-(L-CYSTEINYLAMINO)-2-DEOXY-ALPHA-L-GLUCOPYRANOSIDE'>MA8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [http://pdbe.org/2c27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [http://www.ebi.ac.uk/pdbsum/2c27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c27 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c27 OCA], [https://pdbe.org/2c27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c27 RCSB], [https://www.ebi.ac.uk/pdbsum/2c27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c27 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MSHD_MYCTU MSHD_MYCTU]] Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.<ref>PMID:12375100</ref>
[https://www.uniprot.org/uniprot/MSHD_MYCTU MSHD_MYCTU] Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.<ref>PMID:12375100</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 33: Line 33:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Myctu]]
[[Category: Large Structures]]
[[Category: Blanchard, J S]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Rendle, P M]]
[[Category: Blanchard JS]]
[[Category: Vetting, M W]]
[[Category: Rendle PM]]
[[Category: Yu, M]]
[[Category: Vetting MW]]
[[Category: Acetyltransferase]]
[[Category: Yu M]]
[[Category: Des- acetylmycothiol]]
[[Category: Gcn5 related n- acetyltransferase]]
[[Category: Gnat]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycothiol synthase]]
[[Category: Synthase]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA