2c1m: Difference between revisions

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 ==Nup50:importin-alpha complex==
-<StructureSection load='2c1m' size='340' side='right' caption='[[2c1m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+<StructureSection load='2c1m' size='340' side='right'caption='[[2c1m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2c1m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C1M FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2c1m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C1M FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ejl|1ejl]], [[1ejy|1ejy]], [[1ial|1ial]], [[1iq1|1iq1]], [[1pjm|1pjm]], [[1pjn|1pjn]], [[1q1s|1q1s]], [[1q1t|1q1t]], [[1y2a|1y2a]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1m OCA], [http://pdbe.org/2c1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c1m RCSB], [http://www.ebi.ac.uk/pdbsum/2c1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c1m ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c1m OCA], [https://pdbe.org/2c1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c1m RCSB], [https://www.ebi.ac.uk/pdbsum/2c1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c1m ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/NUP50_MOUSE NUP50_MOUSE]] Note=Defects in Nup50 are the cause of neural tube defects, exencephaly and intrauterine growth retardation.
 == Function ==
-[[http://www.uniprot.org/uniprot/IMA2_MOUSE IMA2_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [[http://www.uniprot.org/uniprot/NUP50_MOUSE NUP50_MOUSE]] Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.<ref>PMID:16222336</ref>
+[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 32: / Line 30: @@
 ==See Also==
-*[[Importin|Importin]]
+*[[Importin 3D structures|Importin 3D structures]]
-*[[Nucleoporin|Nucleoporin]]
+*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Lk3 transgenic mice]]
+[[Category: Large Structures]]
-[[Category: Matsuura, Y]]
+[[Category: Mus musculus]]
-[[Category: Stewart, M]]
+[[Category: Matsuura Y]]
-[[Category: Importin-alpha]]
+[[Category: Stewart M]]
-[[Category: Nuclear protein]]
-[[Category: Nuclear transport-complex]]
-[[Category: Nuclear transport-complex nup50]]
-[[Category: Nucleoporin nup50]]
-[[Category: Protein transport]]
-[[Category: Protein transport-membrane protein complex]]
-[[Category: Protein transport/membrane protein]]