2ble: Difference between revisions
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<StructureSection load='2ble' size='340' side='right'caption='[[2ble]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='2ble' size='340' side='right'caption='[[2ble]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ble]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2ble]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BLE FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ble FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ble OCA], [https://pdbe.org/2ble PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ble RCSB], [https://www.ebi.ac.uk/pdbsum/2ble PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ble ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GMPR1_HUMAN GMPR1_HUMAN] Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.<ref>PMID:1694726</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ble ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ble ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith C]] | ||
[[Category: Bunkoczi | [[Category: Bunkoczi G]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Gileadi O]] | ||
[[Category: Gileadi | [[Category: Haroniti A]] | ||
[[Category: Haroniti | [[Category: Ng S]] | ||
[[Category: Ng | [[Category: Oppermann U]] | ||
[[Category: Oppermann | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Von Delft F]] | ||
[[Category: | |||
Latest revision as of 16:43, 13 December 2023
Structure of human guanosine monophosphate reductase GMPR1 in complex with GMPStructure of human guanosine monophosphate reductase GMPR1 in complex with GMP
Structural highlights
FunctionGMPR1_HUMAN Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References |
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