2bji: Difference between revisions
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<StructureSection load='2bji' size='340' side='right'caption='[[2bji]], [[Resolution|resolution]] 1.24Å' scene=''> | <StructureSection load='2bji' size='340' side='right'caption='[[2bji]], [[Resolution|resolution]] 1.24Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2bji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BJI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.24Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bji OCA], [https://pdbe.org/2bji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bji RCSB], [https://www.ebi.ac.uk/pdbsum/2bji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bji ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bji OCA], [https://pdbe.org/2bji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bji RCSB], [https://www.ebi.ac.uk/pdbsum/2bji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bji ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/IMPA1_BOVIN IMPA1_BOVIN] Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate.[UniProtKB:P29218]<ref>PMID:9462881</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bos taurus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Badyal | [[Category: Badyal R]] | ||
[[Category: Coates | [[Category: Coates L]] | ||
[[Category: Cooper | [[Category: Cooper J]] | ||
[[Category: Erskine | [[Category: Erskine P]] | ||
[[Category: Gill | [[Category: Gill R]] | ||
[[Category: Gore | [[Category: Gore M]] | ||
[[Category: Mohammed | [[Category: Mohammed F]] | ||
[[Category: Thompson | [[Category: Thompson D]] | ||
[[Category: Wood | [[Category: Wood S]] | ||