1w21: Difference between revisions

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 <StructureSection load='1w21' size='340' side='right'caption='[[1w21]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1w21]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W21 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1W21 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1w21]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W21 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a14|1a14]], [[1a4g|1a4g]], [[1a4q|1a4q]], [[1b9s|1b9s]], [[1b9t|1b9t]], [[1b9v|1b9v]], [[1bji|1bji]], [[1e8t|1e8t]], [[1e8u|1e8u]], [[1e8v|1e8v]], [[1euu|1euu]], [[1f8b|1f8b]], [[1f8c|1f8c]], [[1f8d|1f8d]], [[1f8e|1f8e]], [[1inf|1inf]], [[1ing|1ing]], [[1inh|1inh]], [[1inv|1inv]], [[1inw|1inw]], [[1inx|1inx]], [[1iny|1iny]], [[1ivb|1ivb]], [[1ivc|1ivc]], [[1ivd|1ivd]], [[1ive|1ive]], [[1ivf|1ivf]], [[1ivg|1ivg]], [[1kit|1kit]], [[1l7f|1l7f]], [[1l7g|1l7g]], [[1l7h|1l7h]], [[1mwe|1mwe]], [[1nca|1nca]], [[1ncb|1ncb]], [[1ncc|1ncc]], [[1ncd|1ncd]], [[1nma|1nma]], [[1nmb|1nmb]], [[1nmc|1nmc]], [[1nn2|1nn2]], [[1nna|1nna]], [[1nnb|1nnb]], [[1nnc|1nnc]], [[1nsb|1nsb]], [[1nsc|1nsc]], [[1nsd|1nsd]], [[1usr|1usr]], [[1usx|1usx]], [[1v2i|1v2i]], [[1v3b|1v3b]], [[1v3c|1v3c]], [[1v3d|1v3d]], [[1v3e|1v3e]], [[1vcj|1vcj]], [[1w1x|1w1x]], [[1w20|1w20]], [[1v0z|1v0z]], [[1w8n|1w8n]], [[1w8o|1w8o]], [[1xoe|1xoe]], [[1xog|1xog]], [[1z4v|1z4v]], [[1z4w|1z4w]], [[1z4x|1z4x]], [[1z4y|1z4y]], [[1z4z|1z4z]], [[1z50|1z50]], [[2bat|2bat]], [[2qwa|2qwa]], [[2qwb|2qwb]], [[2qwc|2qwc]], [[2qwd|2qwd]], [[2qwe|2qwe]], [[2qwf|2qwf]], [[2qwg|2qwg]], [[2qwh|2qwh]], [[2qwi|2qwi]], [[2qwj|2qwj]], [[2qwk|2qwk]], [[2sil|2sil]], [[2sim|2sim]], [[3nn9|3nn9]], [[4nn9|4nn9]], [[5nn9|5nn9]], [[6nn9|6nn9]], [[7nn9|7nn9]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w21 OCA], [https://pdbe.org/1w21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w21 RCSB], [https://www.ebi.ac.uk/pdbsum/1w21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w21 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1w21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w21 OCA], [http://pdbe.org/1w21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w21 RCSB], [http://www.ebi.ac.uk/pdbsum/1w21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w21 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/NRAM_I56A2 NRAM_I56A2]] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
+[https://www.uniprot.org/uniprot/NRAM_I56A2 NRAM_I56A2] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 __TOC__
 </StructureSection>
-[[Category: Exo-alpha-sialidase]]
+[[Category: Influenza A virus]]
 [[Category: Large Structures]]
-[[Category: Crennell, S J]]
+[[Category: Crennell SJ]]
-[[Category: Garman, E F]]
+[[Category: Garman EF]]
-[[Category: Laver, W G]]
+[[Category: Laver WG]]
-[[Category: Rudino-Pinera, E]]
+[[Category: Rudino-Pinera E]]
-[[Category: Tunnah, P]]
+[[Category: Tunnah P]]
-[[Category: Webster, R G]]
+[[Category: Webster RG]]
-[[Category: Hb site]]
-[[Category: Hydrolase]]
-[[Category: Influenza type some]]
-[[Category: Neuraminidase]]
-[[Category: Sialic acid]]
-[[Category: Subtype n6]]