1w0f: Difference between revisions
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<StructureSection load='1w0f' size='340' side='right'caption='[[1w0f]], [[Resolution|resolution]] 2.65Å' scene=''> | <StructureSection load='1w0f' size='340' side='right'caption='[[1w0f]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1w0f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1w0f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W0F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W0F FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0f OCA], [https://pdbe.org/1w0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w0f RCSB], [https://www.ebi.ac.uk/pdbsum/1w0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w0f ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0f OCA], [https://pdbe.org/1w0f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w0f RCSB], [https://www.ebi.ac.uk/pdbsum/1w0f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w0f ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Angove | [[Category: Angove HC]] | ||
[[Category: Cosme | [[Category: Cosme J]] | ||
[[Category: Day | [[Category: Day PJ]] | ||
[[Category: Jhoti | [[Category: Jhoti H]] | ||
[[Category: Tickle | [[Category: Tickle IJ]] | ||
[[Category: Vinkovic | [[Category: Vinkovic DM]] | ||
[[Category: Vonrhein | [[Category: Vonrhein C]] | ||
[[Category: Ward | [[Category: Ward A]] | ||
[[Category: Williams | [[Category: Williams PA]] | ||