1us8: Difference between revisions

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-==THE RAD50 SIGNATURE MOTIF: ESSENTIAL TO ATP BINDING AND BIOLOGICAL FUNCTION==
-<StructureSection load='1us8' size='340' side='right' caption='[[1us8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+==The Rad50 signature motif: essential to ATP binding and biological function==
+<StructureSection load='1us8' size='340' side='right'caption='[[1us8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1us8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1US8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1US8 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1us8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1US8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1US8 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f2t|1f2t]], [[1f2u|1f2u]], [[1ii8|1ii8]], [[1l8d|1l8d]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1us8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1us8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1us8 RCSB], [http://www.ebi.ac.uk/pdbsum/1us8 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1us8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1us8 OCA], [https://pdbe.org/1us8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1us8 RCSB], [https://www.ebi.ac.uk/pdbsum/1us8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1us8 ProSAT]</span></td></tr>
-<table>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RAD50_PYRFU RAD50_PYRFU] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site.[HAMAP-Rule:MF_00449]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/us/1us8_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/us/1us8_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1us8 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 24: / Line 27: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1us8" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Pyrococcus furiosus]]
-[[Category: Alden, E.]]
+[[Category: Alden E]]
-[[Category: Bhaskara, V.]]
+[[Category: Bhaskara V]]
-[[Category: Hopfner, K P.]]
+[[Category: Hopfner KP]]
-[[Category: Karcher, A.]]
+[[Category: Karcher A]]
-[[Category: Lengsfeld, B.]]
+[[Category: Lengsfeld B]]
-[[Category: Moncalian, G.]]
+[[Category: Moncalian G]]
-[[Category: Paull, T T.]]
+[[Category: Paull TT]]
-[[Category: Tainer, J A.]]
+[[Category: Tainer JA]]
-[[Category: Abc atpase]]
-[[Category: Dna repair]]
-[[Category: Signature motif]]