1upw: Difference between revisions

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OCA

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 ==Crystal structure of the human Liver X receptor beta ligand binding domain in complex with a synthetic agonist==
-<StructureSection load='1upw' size='340' side='right' caption='[[1upw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+<StructureSection load='1upw' size='340' side='right'caption='[[1upw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1upw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UPW FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1upw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UPW FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=444:N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE'>444</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p8d|1p8d]], [[1pq6|1pq6]], [[1pq9|1pq9]], [[1pqc|1pqc]], [[1upv|1upv]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=444:N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE'>444</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1upw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1upw OCA], [http://pdbe.org/1upw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1upw RCSB], [http://www.ebi.ac.uk/pdbsum/1upw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1upw ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1upw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1upw OCA], [https://pdbe.org/1upw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1upw RCSB], [https://www.ebi.ac.uk/pdbsum/1upw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1upw ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/NR1H2_HUMAN NR1H2_HUMAN] Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 34: / Line 36: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Budzinski, R M]]
+[[Category: Large Structures]]
-[[Category: Heckel, A]]
+[[Category: Budzinski RM]]
-[[Category: Hoerer, S]]
+[[Category: Heckel A]]
-[[Category: Nar, H]]
+[[Category: Hoerer S]]
-[[Category: Schmid, A]]
+[[Category: Nar H]]
-[[Category: Ligand binding domain]]
+[[Category: Schmid A]]
-[[Category: Liver x receptor]]
-[[Category: Nuclear hormone receptor]]
-[[Category: Receptor]]
-[[Category: Transcription factor]]