1qo1: Difference between revisions

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-[[Image:1qo1.gif|left|200px]]<br /><applet load="1qo1" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1qo1, resolution 3.9&Aring;" />
-'''MOLECULAR ARCHITECTURE OF THE ROTARY MOTOR IN ATP SYNTHASE FROM YEAST MITOCHONDRIA'''<br />
-==Overview==
+==Molecular Architecture of the Rotary Motor in ATP Synthase from Yeast Mitochondria==
-Adenosine triphosphate (ATP) synthase contains a rotary motor involved in, biological energy conversion. Its membrane-embedded F0 sector has a, rotation generator fueled by the proton-motive force, which provides the, energy required for the synthesis of ATP by the F1 domain. An electron, density map obtained from crystals of a subcomplex of yeast mitochondrial, ATP synthase shows a ring of 10 c subunits. Each c subunit forms an, alpha-helical hairpin. The interhelical loops of six to seven of the c, subunits are in close contact with the gamma and delta subunits of the, central stalk. The extensive contact between the c ring and the stalk, suggests that they may rotate as an ensemble during catalysis.
+<StructureSection load='1qo1' size='340' side='right'caption='[[1qo1]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1qo1]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QO1 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qo1 OCA], [https://pdbe.org/1qo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qo1 RCSB], [https://www.ebi.ac.uk/pdbsum/1qo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qo1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ATPA_BOVIN ATPA_BOVIN] Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qo/1qo1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qo1 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Adenosine triphosphate (ATP) synthase contains a rotary motor involved in biological energy conversion. Its membrane-embedded F0 sector has a rotation generator fueled by the proton-motive force, which provides the energy required for the synthesis of ATP by the F1 domain. An electron density map obtained from crystals of a subcomplex of yeast mitochondrial ATP synthase shows a ring of 10 c subunits. Each c subunit forms an alpha-helical hairpin. The interhelical loops of six to seven of the c subunits are in close contact with the gamma and delta subunits of the central stalk. The extensive contact between the c ring and the stalk suggests that they may rotate as an ensemble during catalysis.
-==About this Structure==
+Molecular architecture of the rotary motor in ATP synthase.,Stock D, Leslie AG, Walker JE Science. 1999 Nov 26;286(5445):1700-5. PMID:10576729<ref>PMID:10576729</ref>
-QO1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Active as [http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QO1 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Molecular architecture of the rotary motor in ATP synthase., Stock D, Leslie AG, Walker JE, Science. 1999 Nov 26;286(5445):1700-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10576729 10576729]
+</div>
-[[Category: H(+)-transporting two-sector ATPase]]
+<div class="pdbe-citations 1qo1" style="background-color:#fffaf0;"></div>
-[[Category: Protein complex]]
+==See Also==
+*[[ATPase 3D structures|ATPase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Leslie, A.G.W.]]
+[[Category: Leslie AGW]]
-[[Category: Stock, D.]]
+[[Category: Stock D]]
-[[Category: Walker, J.E.]]
+[[Category: Walker JE]]
-[[Category: atp synthase]]
-[[Category: c-alpha only]]
-[[Category: low resolution model]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 00:50:24 2007''