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==PENICILLIN-BINDING PROTEIN 2X (PBP-2X)==
==PENICILLIN-BINDING PROTEIN 2X (PBP-2X)==
<StructureSection load='1qme' size='340' side='right' caption='[[1qme]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='1qme' size='340' side='right'caption='[[1qme]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1qme]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QME FirstGlance]. <br>
<table><tr><td colspan='2'>[[1qme]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QME FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pmd|1pmd]], [[1qmf|1qmf]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PBP2X ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qme OCA], [https://pdbe.org/1qme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qme RCSB], [https://www.ebi.ac.uk/pdbsum/1qme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qme ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qme OCA], [http://pdbe.org/1qme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qme RCSB], [http://www.ebi.ac.uk/pdbsum/1qme PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1qme ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PBPX_STRPN PBPX_STRPN]] Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.  
[https://www.uniprot.org/uniprot/PBPX_STRPN PBPX_STRPN] Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Penicillin-binding protein|Penicillin-binding protein]]
*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dideberg, O]]
[[Category: Large Structures]]
[[Category: Duee, E]]
[[Category: Streptococcus pneumoniae]]
[[Category: Gordon, E J]]
[[Category: Dideberg O]]
[[Category: Mouz, N]]
[[Category: Duee E]]
[[Category: Cell wall]]
[[Category: Gordon EJ]]
[[Category: Penicillin-binding protein]]
[[Category: Mouz N]]
[[Category: Peptidoglycan synthesis]]
[[Category: Resistance]]
[[Category: Transmembrane]]

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