1ok3: Difference between revisions
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== | |||
<StructureSection load='1ok3' size='340' side='right' caption='[[1ok3]], [[Resolution|resolution]] 2.20Å' scene=''> | ==Decay accelerating factor (cd55): the structure of an intact human complement regulator.== | ||
<StructureSection load='1ok3' size='340' side='right'caption='[[1ok3]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ok3]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1ok3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OK3 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ok3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ok3 OCA], [https://pdbe.org/1ok3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ok3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ok3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ok3 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/DAF_HUMAN DAF_HUMAN] This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.<ref>PMID:7525274</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/1ok3_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ok/1ok3_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ok3 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1ok3" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[CD55|CD55]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Billington | [[Category: Large Structures]] | ||
[[Category: Crispin | [[Category: Billington J]] | ||
[[Category: Dwek | [[Category: Crispin MDM]] | ||
[[Category: Esser | [[Category: Dwek RA]] | ||
[[Category: Evans | [[Category: Esser D]] | ||
[[Category: Lea | [[Category: Evans DJ]] | ||
[[Category: Lukacik | [[Category: Lea SM]] | ||
[[Category: Morgan | [[Category: Lukacik P]] | ||
[[Category: Radcliffe | [[Category: Morgan BP]] | ||
[[Category: Roversi | [[Category: Radcliffe CM]] | ||
[[Category: Rudd | [[Category: Roversi P]] | ||
[[Category: Smith | [[Category: Rudd PM]] | ||
[[Category: Smith | [[Category: Smith GP]] | ||
[[Category: White | [[Category: Smith RAG]] | ||
[[Category: Williams | [[Category: White J]] | ||
[[Category: Wormald | [[Category: Williams PA]] | ||
[[Category: Wormald MR]] | |||