1he3: Difference between revisions
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==Human biliverdin IX beta reductase: NADP/mesobiliverdin IV alpha ternary complex== | ==Human biliverdin IX beta reductase: NADP/mesobiliverdin IV alpha ternary complex== | ||
<StructureSection load='1he3' size='340' side='right' caption='[[1he3]], [[Resolution|resolution]] 1.40Å' scene=''> | <StructureSection load='1he3' size='340' side='right'caption='[[1he3]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1he3]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1he3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HE3 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MBV:MESOBILIVERDIN+IV+ALPHA'>MBV</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1he3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1he3 OCA], [https://pdbe.org/1he3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1he3 RCSB], [https://www.ebi.ac.uk/pdbsum/1he3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1he3 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/BLVRB_HUMAN BLVRB_HUMAN] Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin.<ref>PMID:10620517</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</div> | </div> | ||
<div class="pdbe-citations 1he3" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1he3" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Flavin reductase|Flavin reductase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Coll | [[Category: Coll M]] | ||
[[Category: Cunningham | [[Category: Cunningham O]] | ||
[[Category: Darcy | [[Category: Darcy K]] | ||
[[Category: Macedo-Ribeiro | [[Category: Macedo-Ribeiro S]] | ||
[[Category: Mantle | [[Category: Mantle TJ]] | ||
[[Category: Parraga | [[Category: Parraga A]] | ||
[[Category: Pereira | [[Category: Pereira PJB]] | ||
[[Category: Perez-Luque | [[Category: Perez-Luque R]] | ||