1h96: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1h96.gif|left|200px]]<br />
-<applet load="1h96" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1h96, resolution 1.60&Aring;" />
-'''RECOMBINANT MOUSE L-CHAIN FERRITIN'''<br />
-==Overview==
+==recombinant mouse L-chain ferritin==
-Cubic F432 crystals of recombinant mouse L-chain apoferritin were obtained, by the hanging-drop technique with ammonium sulfate and cadmium sulfate as, precipitants. The structure was refined to 2.1 and 1.6 A resolution from, data obtained at room temperature and under cryogenic conditions, respectively. The structure of an eight-amino-acid loop insertion in the, mouse sequence is found to be highly disordered both at room temperature, and at low temperature.
+<StructureSection load='1h96' size='340' side='right'caption='[[1h96]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1h96]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H96 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h96 OCA], [https://pdbe.org/1h96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h96 RCSB], [https://www.ebi.ac.uk/pdbsum/1h96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h96 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FRIL1_MOUSE FRIL1_MOUSE] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/1h96_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h96 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Cubic F432 crystals of recombinant mouse L-chain apoferritin were obtained by the hanging-drop technique with ammonium sulfate and cadmium sulfate as precipitants. The structure was refined to 2.1 and 1.6 A resolution from data obtained at room temperature and under cryogenic conditions, respectively. The structure of an eight-amino-acid loop insertion in the mouse sequence is found to be highly disordered both at room temperature and at low temperature.
-==About this Structure==
+Structure of mouse L-chain ferritin at 1.6 A resolution.,Granier T, Gallois B, Langlois d'Estaintot B, Dautant A, Chevalier JM, Mellado JM, Beaumont C, Santambrogio P, Arosio P, Precigoux G Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1491-7. Epub 2001, Oct 25. PMID:11679711<ref>PMID:11679711</ref>
-H96 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with CD and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H96 OCA]].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Structure of mouse L-chain ferritin at 1.6 A resolution., Granier T, Gallois B, Langlois d'Estaintot B, Dautant A, Chevalier JM, Mellado JM, Beaumont C, Santambrogio P, Arosio P, Precigoux G, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1491-7. Epub 2001, Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11679711 11679711]
+</div>
+<div class="pdbe-citations 1h96" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Ferritin 3D structures|Ferritin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Arosio P]]
-[[Category: Arosio, P.]]
+[[Category: Beaumont C]]
-[[Category: Beaumont, C.]]
+[[Category: Chevalier JM]]
-[[Category: Chevalier, J.M.]]
+[[Category: D'Estaintot BL]]
-[[Category: Dautant, A.]]
+[[Category: Dautant A]]
-[[Category: Estaintot, B.L.D.]]
+[[Category: Gallois B]]
-[[Category: Gallois, B.]]
+[[Category: Granier T]]
-[[Category: Granier, T.]]
+[[Category: Mellado JM]]
-[[Category: Mellado, J.M.]]
+[[Category: Precigoux G]]
-[[Category: Precigoux, G.]]
+[[Category: Santambrogio P]]
-[[Category: Santambrogio, P.]]
-[[Category: CD]]
-[[Category: SO4]]
-[[Category: iron storage]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 21:53:41 2007''