1h0s: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1h0s.gif|left|200px]]<br />
-<applet load="1h0s" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1h0s, resolution 1.7&Aring;" />
-'''3-DEHYDROQUINATE DEHYDRATASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH 3-HYDROXYIMINO-QUINIC ACID'''<br />
-==About this Structure==
+==3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with 3-hydroxyimino-quinic acid==
-H0S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with SO4, FA6 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] Structure known Active Site: FA6. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H0S OCA].
+<StructureSection load='1h0s' size='340' side='right'caption='[[1h0s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-[[Category: 3-dehydroquinate dehydratase]]
+== Structural highlights ==
-[[Category: Mycobacterium tuberculosis]]
+<table><tr><td colspan='2'>[[1h0s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0S FirstGlance]. <br>
-[[Category: Single protein]]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-[[Category: Abell, C.]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FA6:3-HYDROXYIMINO+QUINIC+ACID'>FA6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Coggins, J.R.]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0s OCA], [https://pdbe.org/1h0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0s RCSB], [https://www.ebi.ac.uk/pdbsum/1h0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0s ProSAT]</span></td></tr>
-[[Category: Frederickson, M.]]
+</table>
-[[Category: Lapthorn, A.J.]]
+== Function ==
-[[Category: Roszak, A.W.]]
+[https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
-[[Category: FA6]]
+== Evolutionary Conservation ==
-[[Category: GOL]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: SO4]]
+Check<jmol>
-[[Category: alpha/beta protein]]
+  <jmolCheckbox>
-[[Category: dehydratase]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h0s_consurf.spt"</scriptWhenChecked>
-[[Category: shikimate pathway]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h0s ConSurf].
+<div style="clear:both"></div>
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov  5 16:25:01 2007''
+==See Also==
+*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
+[[Category: Abell C]]
+[[Category: Coggins JR]]
+[[Category: Frederickson M]]
+[[Category: Lapthorn AJ]]
+[[Category: Roszak AW]]