1h0s: Difference between revisions

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[[Image:1h0s.png|left|200px]]


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==3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with 3-hydroxyimino-quinic acid==
The line below this paragraph, containing "STRUCTURE_1h0s", creates the "Structure Box" on the page.
<StructureSection load='1h0s' size='340' side='right'caption='[[1h0s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1h0s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H0S FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FA6:3-HYDROXYIMINO+QUINIC+ACID'>FA6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1h0s| PDB=1h0s |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h0s OCA], [https://pdbe.org/1h0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h0s RCSB], [https://www.ebi.ac.uk/pdbsum/1h0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h0s ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h0/1h0s_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h0s ConSurf].
<div style="clear:both"></div>


===3-DEHYDROQUINATE DEHYDRATASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH 3-HYDROXYIMINO-QUINIC ACID===
==See Also==
 
*[[Dehydroquinase 3D structures|Dehydroquinase 3D structures]]
 
__TOC__
<!--
</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_10360352}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 10360352 is the PubMed ID number.
[[Category: Mycobacterium tuberculosis H37Rv]]
-->
[[Category: Abell C]]
{{ABSTRACT_PUBMED_10360352}}
[[Category: Coggins JR]]
 
[[Category: Frederickson M]]
==About this Structure==
[[Category: Lapthorn AJ]]
[[1h0s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H0S OCA].
[[Category: Roszak AW]]
 
==Reference==
<ref group="xtra">PMID:010360352</ref><ref group="xtra">PMID:016952136</ref><references group="xtra"/>
[[Category: 3-dehydroquinate dehydratase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Abell, C.]]
[[Category: Coggins, J R.]]
[[Category: Frederickson, M.]]
[[Category: Lapthorn, A J.]]
[[Category: Roszak, A W.]]
[[Category: Alpha/beta protein]]
[[Category: Lyase]]
[[Category: Shikimate pathway]]

Latest revision as of 15:12, 13 December 2023

3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with 3-hydroxyimino-quinic acid3-dehydroquinate dehydratase from Mycobacterium tuberculosis in complex with 3-hydroxyimino-quinic acid

Structural highlights

1h0s is a 1 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AROQ_MYCTU Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1h0s, resolution 1.70Å

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