1e8k: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1e8k.gif|left|200px]]<br />
-<applet load="1e8k" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1e8k, resolution 1.90&Aring;" />
-'''CYCLOPHILIN 3 COMPLEXED WITH DIPEPTIDE ALA-PRO'''<br />
-==About this Structure==
+==Cyclophilin 3 Complexed With Dipeptide Ala-Pro==
-E8K is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]] with ALA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: CBS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E8K OCA]].
+<StructureSection load='1e8k' size='340' side='right'caption='[[1e8k]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1e8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E8K FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e8k OCA], [https://pdbe.org/1e8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e8k RCSB], [https://www.ebi.ac.uk/pdbsum/1e8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e8k ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CYP3_CAEEL CYP3_CAEEL] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/1e8k_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e8k ConSurf].
+<div style="clear:both"></div>
-==Reference==
+==See Also==
-The First Direct Determination of a Ligand Binding Constant in Protein Crystals., Wu Sy S, Dornan J, Kontopidis G, Taylor P, Walkinshaw MD, Angew Chem Int Ed Engl. 2001 Feb 2;40(3):582-586. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11180378 11180378]
+*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Caenorhabditis elegans]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Dornan, J.]]
+[[Category: Dornan J]]
-[[Category: Kontopidis, G.]]
+[[Category: Kontopidis G]]
-[[Category: Taylor, P.]]
+[[Category: Taylor P]]
-[[Category: Walkinshaw, M.D.]]
+[[Category: Walkinshaw MD]]
-[[Category: Wu, S.Y.]]
+[[Category: Wu SY]]
-[[Category: ALA]]
-[[Category: isomerase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:08:19 2007''