1e3k: Difference between revisions
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<StructureSection load='1e3k' size='340' side='right' caption='[[1e3k]], [[Resolution|resolution]] 2.80Å' scene=''> | ==Human Progesteron Receptor Ligand Binding Domain in complex with the ligand metribolone (R1881)== | ||
<StructureSection load='1e3k' size='340' side='right'caption='[[1e3k]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1e3k]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1e3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E3K FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R18:(17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE'>R18</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e3k OCA], [https://pdbe.org/1e3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e3k RCSB], [https://www.ebi.ac.uk/pdbsum/1e3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e3k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/1e3k_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/1e3k_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e3k ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1e3k" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1e3k" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Progesterone receptor|Progesterone receptor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Basler | [[Category: Large Structures]] | ||
[[Category: Carrondo | [[Category: Basler S]] | ||
[[Category: Coelho | [[Category: Carrondo MA]] | ||
[[Category: Donner | [[Category: Coelho R]] | ||
[[Category: Egner | [[Category: Donner P]] | ||
[[Category: Joschko | [[Category: Egner U]] | ||
[[Category: Macedo | [[Category: Joschko S]] | ||
[[Category: Matias | [[Category: Macedo S]] | ||
[[Category: Otto | [[Category: Matias PM]] | ||
[[Category: Peixoto | [[Category: Otto N]] | ||
[[Category: Schafer | [[Category: Peixoto C]] | ||
[[Category: Scholz | [[Category: Schafer M]] | ||
[[Category: Thomaz | [[Category: Scholz P]] | ||
[[Category: Wegg | [[Category: Thomaz M]] | ||
[[Category: Wegg A]] | |||